Quality variation of sibjeondaebotang according to long-term storage

Abstract

The purpose of this study was to evaluate of quality variation of Sibujeondaebotang according to storage period and temperature (5 and 25 °C) Identificaion test, pH, specific gravity, heavy metal, microbial limit test and glycyrrhizic acid, paeoniflorin content of Sibjeondaebotang were performed during 12 months. The significant change was not shown on identificaion test, specific gravity, microbial limit test under long term storage and the result suited a safe level standards of ‘Korean National Standard of Traditional Medicinal (Herbal and Botanical) Materials - Sibjeondaebotang'. The test of pH showed meaningful changes between two storage temperature (5 and 25 °C) according to increasing storage period. The contents of glycyrrhizic acid and paeoniflorin had no relation with storage temperature(5 °C, 25 °C) but it showed a tendency to decrease according to the length of storage period. We predicted shelf-life of glycyrrhizic acid and paeoniflorin at storgae temperature(5 and 25 °C) as about 6 and 3 months, respecttively. Therefore considering glycyrrhizic acid and paeoniflorin, sibjeondaebotang is determined to be in good condition within 3 months, regardless of the room temperature and refrigerated temperature. We were expected to serve as a basis for the guideline of medication counseling sibjeondaebotang. © 2016 Korean Society of Pharmacognosy. All rights reserved.