AKT regulates IL-1 beta-induced proliferation and activation of hepatic stellate cells
DC Field | Value | Language |
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dc.contributor.author | Yoon, Yongdae | - |
dc.contributor.author | Hwang, Soonjae | - |
dc.contributor.author | Saima, Fatema Tuj | - |
dc.contributor.author | Kim, Moon Young | - |
dc.contributor.author | Baik, Soon Koo | - |
dc.contributor.author | Eom, Young Woo | - |
dc.date.accessioned | 2023-05-17T00:42:10Z | - |
dc.date.available | 2023-05-17T00:42:10Z | - |
dc.date.created | 2023-05-15 | - |
dc.date.issued | 2023-03 | - |
dc.identifier.issn | 0327-9545 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/87796 | - |
dc.description.abstract | Background: Activated hepatic stellate cells (HSCs) are closely involved in the initiation, perpetuation, and resolution of liver fibrosis. Pro-inflammatory cytokine levels are positively correlated with the transition from liver injury to fibrogenesis and contribute to HSC pathophysiology in liver fibrosis.Methods: In this study, we investigated the effect of the pro-inflammatory cytokine interleukin (IL)-1(3 on the proliferation and signaling pathways involved in fibrogenesis in LX-2 cells, an HSC cell line, using western blotting and cell proliferation assays.Results: IL-1(3 increased the proliferation rate and a-smooth muscle actin (SMA) expression of LX-2 cells in a dose-dependent manner. Within 1 h after IL-1(3 treatment, c-Jun N-terminal kinase (JNK), p38, and nuclear factor-KB (NF-KB) signaling was activated in LX-2 cells. Subsequently, protein kinase B (AKT) phosphorylation and an increase in aSMA expression were observed in LX-2 cells. Each inhibitor of JNK, p38, or NF-KB decreased cell proliferation, AKT phosphorylation, and a-SMA expression in IL-1(3-treated LX-2 cells. Conclusion: These results indicate that JNK, p38, and NF-KB signals converge at AKT phosphorylation, leading to LX-2 activation by IL-1(3. Therefore, the AKT signaling pathway can be used as a target for alleviating liver fibrosis by the inflammatory cytokine IL-1(3. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | TECH SCIENCE PRESS | - |
dc.relation.isPartOf | BIOCELL | - |
dc.title | AKT regulates IL-1 beta-induced proliferation and activation of hepatic stellate cells | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000974000500004 | - |
dc.identifier.doi | 10.32604/biocell.2023.025365 | - |
dc.identifier.bibliographicCitation | BIOCELL, v.47, no.3, pp.669 - 676 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85150193757 | - |
dc.citation.endPage | 676 | - |
dc.citation.startPage | 669 | - |
dc.citation.title | BIOCELL | - |
dc.citation.volume | 47 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | Hwang, Soonjae | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Hepatic stellate cell | - |
dc.subject.keywordAuthor | Interleukin-1(3 | - |
dc.subject.keywordAuthor | AKT | - |
dc.subject.keywordAuthor | Cell proliferation | - |
dc.subject.keywordAuthor | Fibrosis | - |
dc.subject.keywordPlus | EPITHELIAL-MESENCHYMAL TRANSITION | - |
dc.subject.keywordPlus | RESIDENT FIBROBLASTS | - |
dc.subject.keywordPlus | FIBROSIS | - |
dc.subject.keywordPlus | MYOFIBROBLASTS | - |
dc.subject.keywordPlus | PATHOGENESIS | - |
dc.subject.keywordPlus | CONTRIBUTES | - |
dc.subject.keywordPlus | PROGRESSION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | BIOLOGY | - |
dc.subject.keywordPlus | INJURY | - |
dc.relation.journalResearchArea | Life Sciences & Biomedicine - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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