The association between vitamin D deficiency and risk of renal event: Results from the Korean cohort study for outcomes in patients with chronic kidney disease (KNOW-CKD)
DC Field | Value | Language |
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dc.contributor.author | Lee, Juyeon | - |
dc.contributor.author | Bae, Eun Hui | - |
dc.contributor.author | Kim, Soo Wan | - |
dc.contributor.author | Chung, Wookyung | - |
dc.contributor.author | Kim, Yeong Hoon | - |
dc.contributor.author | Oh, Yun Kyu | - |
dc.contributor.author | Kim, Yong-Soo | - |
dc.contributor.author | Oh, Kook-Hwan | - |
dc.contributor.author | Park, Sue K. | - |
dc.date.accessioned | 2023-05-17T00:42:50Z | - |
dc.date.available | 2023-05-17T00:42:50Z | - |
dc.date.created | 2023-05-08 | - |
dc.date.issued | 2023-02 | - |
dc.identifier.issn | 2296-858X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/87804 | - |
dc.description.abstract | BackgroundsSome observational studies have suggested a possible association between vitamin D deficiency and CKD. However, in most studies, the causality between low levels of vitamin D and risk of renal events could not be explained. We investigated the relationship between vitamin D deficiency and risk of severe CKD stage and renal event in a large-scale prospective cohort study. MethodsWe used data from a prospective cohort of 2,144 patients with available information on serum 25-hydroxyvitamin D (25(OH)D) levels at baseline from KNOW-CKD, 2011-2015 were included. Vitamin D deficiency was defined as serum 25(OH)D levels < 15 ng/mL. We performed a cross-sectional analysis to elucidate the relationship between 25(OH)D and CKD stage using baseline CKD patient data. We further examined a cohort analysis to clarify the association between 25(OH)D and risk of renal event. Renal event was a composite of the first occurrence of a 50% decline in eGFR from the baseline value or the onset of CKD stage 5 (initiation of dialysis or kidney transplantation) across the follow-up period. We also investigated the associations of vitamin D deficiency with risk of renal event according to diabetes and overweight status. ResultsVitamin D deficiency were significantly associated with an increased risk of severe CKD stage - 1.30-fold (95% CI: 1.10-1.69) for 25(OH)D. Deficiency of 25(OH)D with 1.64-fold (95% CI: 1.32-2.65) was related to renal event compared with the reference. Furthermore, vitamin D deficiency patients with presence of DM and overweight status also displayed higher risk than non-deficient patients for risk of renal event. ConclusionVitamin D deficiency is associated with significantly increased risk of severe CKD stage and renal event. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | FRONTIERS MEDIA SA | - |
dc.relation.isPartOf | FRONTIERS IN MEDICINE | - |
dc.title | The association between vitamin D deficiency and risk of renal event: Results from the Korean cohort study for outcomes in patients with chronic kidney disease (KNOW-CKD) | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000941702900001 | - |
dc.identifier.doi | 10.3389/fmed.2023.1017459 | - |
dc.identifier.bibliographicCitation | FRONTIERS IN MEDICINE, v.10 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85149542730 | - |
dc.citation.title | FRONTIERS IN MEDICINE | - |
dc.citation.volume | 10 | - |
dc.contributor.affiliatedAuthor | Chung, Wookyung | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | vitamin D deficiency (VDD) | - |
dc.subject.keywordAuthor | renal event | - |
dc.subject.keywordAuthor | CKD stage | - |
dc.subject.keywordAuthor | propensity score match | - |
dc.subject.keywordAuthor | cohort study [or longitudinal study] | - |
dc.subject.keywordPlus | POSITION STATEMENT | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | HEALTH | - |
dc.subject.keywordPlus | CLASSIFICATION | - |
dc.subject.keywordPlus | HYPERTENSION | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | SYSTEM | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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