Methoxyflavones from Black Ginger (Kaempferia parviflora Wall. ex Baker) and their Inhibitory Effect on Melanogenesis in B16F10 Mouse Melanoma Cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Huo, Chen | - |
dc.contributor.author | Lee, Sullim | - |
dc.contributor.author | Yoo, Min Jeong | - |
dc.contributor.author | Lee, Bum Soo | - |
dc.contributor.author | Jang, Yoon Seo | - |
dc.contributor.author | Kim, Ho Kyong | - |
dc.contributor.author | Lee, Seulah | - |
dc.contributor.author | Bae, Han Yong | - |
dc.contributor.author | Kim, Ki Hyun | - |
dc.date.accessioned | 2023-05-17T01:41:11Z | - |
dc.date.available | 2023-05-17T01:41:11Z | - |
dc.date.created | 2023-05-08 | - |
dc.date.issued | 2023-03 | - |
dc.identifier.issn | 2223-7747 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/87819 | - |
dc.description.abstract | Kaempferia parviflora Wall. ex Baker (Zingiberaceae), commonly known as Thai ginseng or black ginger, is a tropical medicinal plant in many regions. It has been traditionally used to treat various ailments, including ulcers, dysentery, gout, allergies, abscesses, and osteoarthritis. As part of our ongoing phytochemical study aimed at discovering bioactive natural products, we investigated potential bioactive methoxyflavones from K. parviflora rhizomes. Phytochemical analysis aided by liquid chromatography-mass spectrometry (LC-MS) led to the isolation of six methoxyflavones (1-6) from the n-hexane fraction of the methanolic extract of K. parviflora rhizomes. The isolated compounds were structurally determined to be 3,7-dimethoxy-5-hydroxyflavone (1), 5-hydroxy-7-methoxyflavone (2), 7,4 '-dimethylapigenin (3), 3,5,7-trimethoxyflavone (4), 3,7,4 '-trimethylkaempferol (5), and 5-hydroxy-3,7,3 ',4 '-tetramethoxyflavone (6), based on NMR data and LC-MS analysis. All of the isolated compounds were evaluated for their anti-melanogenic activities. In the activity assay, 7,4 '-dimethylapigenin (3) and 3,5,7-trimethoxyflavone (4) significantly inhibited tyrosinase activity and melanin content in IBMX-stimulated B16F10 cells. In addition, structure-activity relationship analysis revealed that the methoxy group at C-5 in methoxyflavones is key to their anti-melanogenic activity. This study experimentally demonstrated that K. parviflora rhizomes are rich in methoxyflavones and can be a valuable natural resource for anti-melanogenic compounds. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | PLANTS-BASEL | - |
dc.title | Methoxyflavones from Black Ginger (Kaempferia parviflora Wall. ex Baker) and their Inhibitory Effect on Melanogenesis in B16F10 Mouse Melanoma Cells | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000946865700001 | - |
dc.identifier.doi | 10.3390/plants12051183 | - |
dc.identifier.bibliographicCitation | PLANTS-BASEL, v.12, no.5 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85150158395 | - |
dc.citation.title | PLANTS-BASEL | - |
dc.citation.volume | 12 | - |
dc.citation.number | 5 | - |
dc.contributor.affiliatedAuthor | Lee, Sullim | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Kaempferia parviflora | - |
dc.subject.keywordAuthor | Zingiberaceae | - |
dc.subject.keywordAuthor | Methoxyflavones | - |
dc.subject.keywordAuthor | Anti-melanogenesis | - |
dc.subject.keywordAuthor | SAR | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | SKIN | - |
dc.subject.keywordPlus | MELANOCYTES | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | PIGMENTATION | - |
dc.subject.keywordPlus | TYROSINASE | - |
dc.subject.keywordPlus | EXTRACT | - |
dc.subject.keywordPlus | ACID | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.