Anti-Inflammatory, Neurotrophic, and Cytotoxic Oxylipins Isolated from Chaenomeles sinensis Twigs
DC Field | Value | Language |
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dc.contributor.author | Lee, Da Yeong | - |
dc.contributor.author | Park, Kyoung Jin | - |
dc.contributor.author | Subedi, Lalita | - |
dc.contributor.author | Lee, Gyu Sung | - |
dc.contributor.author | Lee, Ji-Hyeok | - |
dc.contributor.author | Lee, Won-Min | - |
dc.contributor.author | Choi, Sang Un | - |
dc.contributor.author | Hong, Seong-Min | - |
dc.contributor.author | Kim, Sun Yeou | - |
dc.contributor.author | Kim, Chung Sub | - |
dc.date.accessioned | 2023-05-17T02:53:24Z | - |
dc.date.available | 2023-05-17T02:53:24Z | - |
dc.date.created | 2023-05-08 | - |
dc.date.issued | 2023-02 | - |
dc.identifier.issn | 2076-3921 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/87863 | - |
dc.description.abstract | Oxylipins are important biological molecules with diverse roles in human and plants such as pro-/anti-inflammatory, antimicrobial, and regulatory activity. Although there is an increasing number of plant-derived oxylipins, most of their physiological roles in humans remain unclear. Here, we describe the isolation, identification, and biological activities of four new oxylipins, chaenomesters A-D (1-4), along with a known compound (5), obtained from Chaenomeles sinensis twigs. Their chemical structures were determined by spectroscopic (i.e., NMR) and spectrometric (i.e., HRMS) data analysis including H-1 NMR-based empirical rules and homonuclear-decoupled H-1 NMR experiments. Chaenomester D (4), an omega-3 oxylipin, showed a potent inhibitory effect on nitric oxide (NO) production in lipopolysaccharide (LPS)-activated BV-2 cells (NO production, 8.46 +/- 0.68 mu M), neurotrophic activity in C6 cells through the induction of the secretion of nerve growth factor (NGF, 157.7 +/- 2.4%), and cytotoxicity in A549 human cancer cell lines (IC50 = 27.4 mu M). | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | ANTIOXIDANTS | - |
dc.title | Anti-Inflammatory, Neurotrophic, and Cytotoxic Oxylipins Isolated from Chaenomeles sinensis Twigs | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000938287600001 | - |
dc.identifier.doi | 10.3390/antiox12020284 | - |
dc.identifier.bibliographicCitation | ANTIOXIDANTS, v.12, no.2 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85149223090 | - |
dc.citation.title | ANTIOXIDANTS | - |
dc.citation.volume | 12 | - |
dc.citation.number | 2 | - |
dc.contributor.affiliatedAuthor | Subedi, Lalita | - |
dc.contributor.affiliatedAuthor | Hong, Seong-Min | - |
dc.contributor.affiliatedAuthor | Kim, Sun Yeou | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Chaenomeles sinensis | - |
dc.subject.keywordAuthor | oxylipins | - |
dc.subject.keywordAuthor | anti-inflammation | - |
dc.subject.keywordAuthor | neurotrophic effect | - |
dc.subject.keywordAuthor | cytotoxicity | - |
dc.subject.keywordPlus | FATTY-ACIDS | - |
dc.subject.keywordPlus | BIOSYNTHESIS | - |
dc.subject.keywordPlus | CONSTITUENTS | - |
dc.subject.keywordPlus | ADJUVANT | - |
dc.subject.keywordPlus | LEAVES | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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