Unsaturated Fatty Acids Complex Regulates Inflammatory Cytokine Production through the Hyaluronic Acid Pathway
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Gi-Beum | - |
dc.contributor.author | Seo, Kwansung | - |
dc.contributor.author | Youn, Jong-Ung | - |
dc.contributor.author | Kwon, Il Keun | - |
dc.contributor.author | Park, Jinny | - |
dc.contributor.author | Park, Kwang-Hyun | - |
dc.contributor.author | Kim, Jong-Suk | - |
dc.date.accessioned | 2023-05-23T01:44:41Z | - |
dc.date.available | 2023-05-23T01:44:41Z | - |
dc.date.created | 2023-05-22 | - |
dc.date.issued | 2023-04 | - |
dc.identifier.issn | 1420-3049 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/87963 | - |
dc.description.abstract | In this study, we aimed to develop natural and/or functional materials with antioxidant and anti-inflammatory effects. We obtained extracts from natural plants through an oil and hot-water extraction process and prepared an extract composite of an effective unsaturated fatty acid complex (EUFOC). Furthermore, the antioxidant effect of the extract complex was evaluated, and the anti-inflammatory effect was explored by assessing its inhibitory effect on nitric oxide production through its HA-promoting effect. We conducted a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay to evaluate the cell viability of the EUFOC, and the results showed that EUFOC was not cytotoxic at the test concentrations. In addition, it showed no endogenous cytotoxicity in HaCaT (human keratinocyte) cells. The EUFOC showed excellent 1,1-diphenyl-2-picrylhydrazyl- and superoxide-scavenging abilities. Moreover, it exerted an inhibitory effect on NO production at concentrations that did not inhibit cell viability. The secretion of all the cytokines was increased by lipopolysaccharide (LPS) treatment; however, this was inhibited by the EUFOC in a concentration-dependent manner. In addition, hyaluronic acid content was markedly increased by the EUFOC in a dose-dependent manner. These results suggest that the EUFOC has excellent anti-inflammatory and antioxidant properties, and hence, it can be used as a functional material in various fields. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | MOLECULES | - |
dc.title | Unsaturated Fatty Acids Complex Regulates Inflammatory Cytokine Production through the Hyaluronic Acid Pathway | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000977334600001 | - |
dc.identifier.doi | 10.3390/molecules28083554 | - |
dc.identifier.bibliographicCitation | MOLECULES, v.28, no.8 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85156113805 | - |
dc.citation.title | MOLECULES | - |
dc.citation.volume | 28 | - |
dc.citation.number | 8 | - |
dc.contributor.affiliatedAuthor | Park, Jinny | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | plant-derived unsaturated fatty acid | - |
dc.subject.keywordAuthor | antioxidant | - |
dc.subject.keywordAuthor | anti-inflammatory | - |
dc.subject.keywordAuthor | hyaluronic acid | - |
dc.subject.keywordAuthor | hyaluronic acid synthase | - |
dc.subject.keywordPlus | NITRIC-OXIDE SYNTHASE | - |
dc.subject.keywordPlus | HUMAN KERATINOCYTES | - |
dc.subject.keywordPlus | FREE-RADICALS | - |
dc.subject.keywordPlus | SKIN | - |
dc.subject.keywordPlus | CYCLOOXYGENASE-2 | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PHENOTYPE | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | INOS | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.