Busulfan, Melphalan, and Etoposide (BuME) Showed an Equivalent Effect to Busulfan, Cyclophosphamide, and Etoposide (BuCE) as Conditioning Therapy for Autologous Stem Cell Transplantation in Patients with Relapsed or High-Risk Non-Hodgkin's Lymphoma: A Multicenter Randomized Phase II Study by the Consortium for Improving Survival of Lymphoma (CISL)
DC Field | Value | Language |
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dc.contributor.author | Kim, Kyoung Ha | - |
dc.contributor.author | Lee, Jae Hoon | - |
dc.contributor.author | Lee, Mark | - |
dc.contributor.author | Kim, Hoon-Gu | - |
dc.contributor.author | Do, Young Rok | - |
dc.contributor.author | Park, Yong | - |
dc.contributor.author | Oh, Sung Yong | - |
dc.contributor.author | Shin, Ho-Jin | - |
dc.contributor.author | Kim, Won Seog | - |
dc.contributor.author | Park, Seong Kyu | - |
dc.contributor.author | Kong, Jee Hyun | - |
dc.contributor.author | Park, Moo-Rim | - |
dc.contributor.author | Yang, Deok-Hwan | - |
dc.contributor.author | Kwak, Jae-Yong | - |
dc.contributor.author | Kang, Hye Jin | - |
dc.contributor.author | Mun, Yeung-Chul | - |
dc.contributor.author | Won, Jong-Ho | - |
dc.date.accessioned | 2023-05-23T08:41:58Z | - |
dc.date.available | 2023-05-23T08:41:58Z | - |
dc.date.created | 2023-05-23 | - |
dc.date.issued | 2023-01 | - |
dc.identifier.issn | 1598-2998 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/87981 | - |
dc.description.abstract | Purpose High-dose chemotherapy followed by autologous stem cell transplantation (ASCT) is the standard management for relapsed or high-risk non-Hodgkin's lymphoma (NHL). We reported the busulfan, melphalan, and etoposide (BuME) conditioning regimen was effective in patients with relapsed or high-risk NHL. Moreover, the busulfan, cyclophosphamide, and etoposide (BuCE) conditioning regimen has been used widely in ASCT for NHL. Therefore, based on these encouraging results, this randomized phase II multicenter trial compared the outcomes of BuME and BuCE as conditioning therapies for ASCT in patients with NHL.Materials and Methods Patients were randomly assigned to receive either BuME (n=36) or BuCE (n=39). The BuME regimen was comprised of busulfan (3.2 mg/kg/day, intravenously) administered on days -7, -6, and -5, etoposide (400 mg/m2 intravenously) on days -5 and -4, and melphalan (50 mg/m2/day intravenously) on days -3 and -2. The BuCE regimen was comprised of busulfan (3.2 mg/kg/day intravenously) on days -7, -6, and -5, etoposide (400 mg/m2/day intravenously) on days -5 and -4, and cyclophos-phamide (50 mg/kg/day intravenously) on days -3 and -2. The primary endpoint was 2-year progression-free survival (PFS).Results Seventy-five patients were enrolled. Eleven patients (30.5%) in the BuME group and 13 patients (33.3%) in the BuCE group had disease progression or died. The 2-year PFS rate was 65.4% in the BuME group and 60.6% in the BuCE group (p=0.746). There were no non-relapse mortalities within 100 days after transplantation.Conclusion There were no significant differences in PFS between the two groups. Therefore, busulfan-based conditioning regimens, BuME and BuCE, may be important treatment substitutes for the BCNU-containing regimens. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN CANCER ASSOCIATION | - |
dc.relation.isPartOf | CANCER RESEARCH AND TREATMENT | - |
dc.title | Busulfan, Melphalan, and Etoposide (BuME) Showed an Equivalent Effect to Busulfan, Cyclophosphamide, and Etoposide (BuCE) as Conditioning Therapy for Autologous Stem Cell Transplantation in Patients with Relapsed or High-Risk Non-Hodgkin's Lymphoma: A Multicenter Randomized Phase II Study by the Consortium for Improving Survival of Lymphoma (CISL) | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000957087400027 | - |
dc.identifier.doi | 10.4143/crt.2022.004 | - |
dc.identifier.bibliographicCitation | CANCER RESEARCH AND TREATMENT, v.55, no.1, pp.304 - 313 | - |
dc.identifier.kciid | ART002923400 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85146363949 | - |
dc.citation.endPage | 313 | - |
dc.citation.startPage | 304 | - |
dc.citation.title | CANCER RESEARCH AND TREATMENT | - |
dc.citation.volume | 55 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Lee, Jae Hoon | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Key words Autologous stem cell transplantation | - |
dc.subject.keywordAuthor | Non-Hodgkin?s lymphoma | - |
dc.subject.keywordAuthor | Busulfan | - |
dc.subject.keywordPlus | BONE-MARROW-TRANSPLANTATION | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.subject.keywordPlus | BEAC | - |
dc.subject.keywordPlus | TOXICITY | - |
dc.subject.keywordPlus | REGIMEN | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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