SARS-CoV-2 N Gene-Targeted Anodic Stripping Voltammetry Sensor Using a Novel CoS-NGQD/Pt@Pd Platform and Au-DNA-CdTe QD Probe
DC Field | Value | Language |
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dc.contributor.author | Selvam, Sathish Panneer | - |
dc.contributor.author | Phan, Le Minh Tu | - |
dc.contributor.author | Cho, Sungbo | - |
dc.date.accessioned | 2023-06-01T11:40:38Z | - |
dc.date.available | 2023-06-01T11:40:38Z | - |
dc.date.issued | 2023-05 | - |
dc.identifier.issn | 2365-709X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/88015 | - |
dc.description.abstract | Rapid screening of individuals infected with severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) is necessary to contain contagion in a large population. Nucleic acid-based gold standard assays are time-consuming, and nucleic acid amplification is mandatory and expensive, impeding the containment of the coronavirus disease 2019 (COVID-19) outbreak. To overcome the aforementioned disadvantages, this study deals with a specially designed gold (Au)-deoxyribonucleic acid (DNA)-cadmium telluride (CdTe) quantum dot (QD) probe to target two sections of the nucleocapsid (N) gene of SARS-CoV-2 ribonucleic acid (RNA) of three variants (B.1.1.529, B.1.617.2, and B.1.351). A duplex-specific nuclease (DSN)-assisted highly selective release of signaling probes enable higher specificity, and an Au-supported DNA probe is incorporated to carry many CdTe QD signaling probes. After dissolution, the generated Cd2+ ions are quantified at the novel cobalt sulfide (CoS)-nitrogen-doped graphene QD (NGQD)/platinum (Pt)@palladium (Pd) electrode with extraordinary sensitivity through square wave anodic stripping voltammetry (SWASV). The developed sensor exhibits a wide range of detection (10 to 10(8) copies mu L-1) and a lower detection limit (0.12 copies mu L-1), without any amplification. The selectivity of the sensor is tested against MERS and HCoV-NL63, and real-time detection is performed on heat-inactivated viral samples, which show excellent selectivity. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | WILEY | - |
dc.title | SARS-CoV-2 N Gene-Targeted Anodic Stripping Voltammetry Sensor Using a Novel CoS-NGQD/Pt@Pd Platform and Au-DNA-CdTe QD Probe | - |
dc.type | Article | - |
dc.identifier.wosid | 000922359300001 | - |
dc.identifier.doi | 10.1002/admt.202201344 | - |
dc.identifier.bibliographicCitation | ADVANCED MATERIALS TECHNOLOGIES, v.8, no.10 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85146996133 | - |
dc.citation.title | ADVANCED MATERIALS TECHNOLOGIES | - |
dc.citation.volume | 8 | - |
dc.citation.number | 10 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | anodic stripping voltammetry | - |
dc.subject.keywordAuthor | duplex specific nuclease and DNA-RNA hybrid | - |
dc.subject.keywordAuthor | hyperspectral imaging | - |
dc.subject.keywordAuthor | severe acute respiratory syndrome-coronavirus-2 | - |
dc.subject.keywordPlus | QUANTUM DOTS | - |
dc.subject.keywordPlus | ULTRASENSITIVE DETECTION | - |
dc.subject.keywordPlus | HYDROGEN EVOLUTION | - |
dc.subject.keywordPlus | DOPED CARBON | - |
dc.subject.keywordPlus | PERFORMANCE | - |
dc.subject.keywordPlus | ELECTRODES | - |
dc.subject.keywordPlus | BIOSENSOR | - |
dc.subject.keywordPlus | STRATEGY | - |
dc.subject.keywordPlus | CELLS | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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