Multi-Targeting Neuroprotective Effects of Syzygium aromaticum Bud Extracts and Their Key Phytocompounds against Neurodegenerative Diseases
DC Field | Value | Language |
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dc.contributor.author | Sharma, Himadri | - |
dc.contributor.author | Kim, Dan Yeong | - |
dc.contributor.author | Shim, Kyu Hwan | - |
dc.contributor.author | Sharma, Niti | - |
dc.contributor.author | An, Seong Soo A. | - |
dc.date.accessioned | 2023-06-26T01:40:30Z | - |
dc.date.available | 2023-06-26T01:40:30Z | - |
dc.date.created | 2023-05-16 | - |
dc.date.issued | 2023-05 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/88217 | - |
dc.description.abstract | Alzheimer’s disease (AD) is a neurodegenerative disease that causes a gradual loss of normal motor and cognitive function. The complex AD pathophysiology involves various factors such as oxidative stress, neuroinflammation, amyloid-beta (Aβ) aggregation, disturbed neurotransmission, and apoptosis. The available drugs suffer from a range of side effects and are not able to cover different aspects of the disease. Therefore, finding a safer therapeutic approach that can affect multiple targets at a time is highly desirable. In the present study, the underlying neuroprotective mechanism of an important culinary spice, Syzygium aromaticum (Clove) extract, and major bioactive compounds were studied in hydrogen peroxide-induced oxidative stress in human neuroblastoma SH-SY5Y cell lines as a model. The extracts were subjected to GC-MS to identify important bioactive components. The extracts and key bio-actives reduced reactive oxygen species (ROS), restored mitochondrial membrane potential (MMP), and provided neuroprotection from H2O2-induced oxidative stress in cell-based assays due to the antioxidant action. They also reduced lipid peroxidation significantly and restored GSH content. Clove extracts have also displayed anti-acetylcholinesterase (AChE) activity, anti-glycation potential, and Aβ aggregation/fibrilization inhibition. The multitarget neuroprotective approach displayed by Clove makes it a potential candidate for AD drug development. © 2023 by the authors. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | International Journal of Molecular Sciences | - |
dc.title | Multi-Targeting Neuroprotective Effects of Syzygium aromaticum Bud Extracts and Their Key Phytocompounds against Neurodegenerative Diseases | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000986777700001 | - |
dc.identifier.doi | 10.3390/ijms24098148 | - |
dc.identifier.bibliographicCitation | International Journal of Molecular Sciences, v.24, no.9 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85159318512 | - |
dc.citation.title | International Journal of Molecular Sciences | - |
dc.citation.volume | 24 | - |
dc.citation.number | 9 | - |
dc.contributor.affiliatedAuthor | Sharma, Himadri | - |
dc.contributor.affiliatedAuthor | Kim, Dan Yeong | - |
dc.contributor.affiliatedAuthor | Shim, Kyu Hwan | - |
dc.contributor.affiliatedAuthor | Sharma, Niti | - |
dc.contributor.affiliatedAuthor | An, Seong Soo A. | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Alzheimer’s disease | - |
dc.subject.keywordAuthor | anti-acetylcholine esterase activity | - |
dc.subject.keywordAuthor | anti-glycation | - |
dc.subject.keywordAuthor | H2O2 induced stress | - |
dc.subject.keywordAuthor | MDS | - |
dc.subject.keywordAuthor | oxidative stress | - |
dc.subject.keywordAuthor | Syzygium aromaticum | - |
dc.subject.keywordPlus | ANTIOXIDANT ACTIVITY | - |
dc.subject.keywordPlus | BETA-CARYOPHYLLENE | - |
dc.subject.keywordPlus | ESSENTIAL OIL | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | EUGENOL | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | CLOVE | - |
dc.subject.keywordPlus | ACETYLCHOLINESTERASE | - |
dc.subject.keywordPlus | ANTICANCER | - |
dc.subject.keywordPlus | GLUTATHIONE | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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