Nectin-4 as a Predictive Marker for Poor Prognosis of Endometrial Cancer with Mismatch Repair Impairment
DC Field | Value | Language |
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dc.contributor.author | Chang, Ha Kyun | - |
dc.contributor.author | Park, Young Hoon | - |
dc.contributor.author | Choi, Jung-A | - |
dc.contributor.author | Kim, Jeong Won | - |
dc.contributor.author | Kim, Jisup | - |
dc.contributor.author | Kim, Hyo Sun | - |
dc.contributor.author | Lee, Hae Nam | - |
dc.contributor.author | Cho, Hanbyoul | - |
dc.contributor.author | Chung, Joon-Yong | - |
dc.contributor.author | Kim, Jae-Hoon | - |
dc.date.accessioned | 2023-06-26T02:40:36Z | - |
dc.date.available | 2023-06-26T02:40:36Z | - |
dc.date.created | 2023-06-22 | - |
dc.date.issued | 2023-05 | - |
dc.identifier.issn | 2072-6694 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/88223 | - |
dc.description.abstract | The adhesion molecule Nectin-4 is a new potential therapeutic target for different types of cancer; however, little is known about its diagnosis significance in endometrial cancer (EC). We found that Nectin-4 expression was significantly higher in EC tissues than in nonadjacent normal tissue. The area under the receiver operating characteristic curve value of 0.922 indicated good diagnostic accuracy for Nectin-4 expression in EC. Furthermore, Nectin-4 expression was associated with DNA mismatch repair (MMR) protein deficiency. Notably, the high Nectin-4 expression group of patients with MSH2/6-deficient EC had shorter progression-free survival than that of the low Nectin-4 expression group. The number of lymphovascular space invasion-positive patients in groups with MMR deficiency and high Nectin-4 expression was also increased compared with that in the low Nectin-4 expression group. Bioinformatics analysis revealed that alteration in Nectin-4 and MMR genes is associated with Nectin-4 expression in EC. To the best of our knowledge, this is the first study to show that Nectin-4 expression may be a potential biomarker for EC diagnosis and that high Nectin-4 expression in MMR-deficient patients with EC can predict short progression-free survival, thus providing clues to identify patients for adjuvant therapy. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | CANCERS | - |
dc.title | Nectin-4 as a Predictive Marker for Poor Prognosis of Endometrial Cancer with Mismatch Repair Impairment | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000996798400001 | - |
dc.identifier.doi | 10.3390/cancers15102865 | - |
dc.identifier.bibliographicCitation | CANCERS, v.15, no.10 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85160694941 | - |
dc.citation.title | CANCERS | - |
dc.citation.volume | 15 | - |
dc.citation.number | 10 | - |
dc.contributor.affiliatedAuthor | Kim, Jisup | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Nectin-4 | - |
dc.subject.keywordAuthor | endometrial cancer | - |
dc.subject.keywordAuthor | MSH2 | - |
dc.subject.keywordAuthor | MSH6 | - |
dc.subject.keywordPlus | MICROSATELLITE INSTABILITY | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | METASTASIS | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | PROGRESSION | - |
dc.subject.keywordPlus | DEFICIENCY | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | RISK | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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