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The Cytoprotective Effects of Baicalein on H2O2-Induced ROS by Maintaining Mitochondrial Homeostasis and Cellular Tight Junction in HaCaT Keratinocytes

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dc.contributor.authorKim, Gyeonghyeon-
dc.contributor.authorHan, Dong-Wook-
dc.contributor.authorLee, Jong Hun-
dc.date.accessioned2023-06-26T15:41:03Z-
dc.date.available2023-06-26T15:41:03Z-
dc.date.created2023-06-26-
dc.date.issued2023-04-
dc.identifier.issn2076-3921-
dc.identifier.urihttps://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/88237-
dc.description.abstractReactive oxygen species (ROS) promote oxidative stress, which directly causes molecular damage and disrupts cellular homeostasis, leading to skin aging. Baicalein, a flavonoid compound isolated from the root of Scutellaria baicalensis Georgi has antioxidant, anticancer, anti-inflammatory, and other medicinal properties. We aimed to investigate the protective effect of baicalein on the disruption of tight junctions and mitochondrial dysfunction caused by H2O2-induced oxidative stress in HaCaT keratinocytes. The cells were pretreated with 20 and 40 mu M baicalein followed by treatment with 500 mu M H2O2. The results revealed that baicalein exerted antioxidant effects by reducing intracellular ROS production. Baicalein attenuated the degradation of the ECM (MMP-1 and Col1A1) and the disruption of tight junctions (ZO-1, occludin, and claudin-4). In addition, baicalein prevented mitochondrial dysfunction (PGC-1 alpha, PINK1, and Parkin) and restored mitochondrial respiration. Furthermore, baicalein regulated the expression of antioxidant enzymes, including NQO-1 and HO-1, via the Nrf2 signaling pathway. Our data suggest that the cytoprotective effects of baicalein against H2O2-induced oxidative stress may be mediated through the Nrf2/NQO-1/HO-1 signaling pathway. In conclusion, baicalein exerts potent antioxidant effects against H2O2-induced oxidative stress in HaCaT keratinocytes by maintaining mitochondrial homeostasis and cellular tight junctions.-
dc.language영어-
dc.language.isoen-
dc.publisherMDPI-
dc.relation.isPartOfANTIOXIDANTS-
dc.titleThe Cytoprotective Effects of Baicalein on H2O2-Induced ROS by Maintaining Mitochondrial Homeostasis and Cellular Tight Junction in HaCaT Keratinocytes-
dc.typeArticle-
dc.type.rimsART-
dc.description.journalClass1-
dc.identifier.wosid000980893700001-
dc.identifier.doi10.3390/antiox12040902-
dc.identifier.bibliographicCitationANTIOXIDANTS, v.12, no.4-
dc.description.isOpenAccessY-
dc.identifier.scopusid2-s2.0-85156232804-
dc.citation.titleANTIOXIDANTS-
dc.citation.volume12-
dc.citation.number4-
dc.contributor.affiliatedAuthorKim, Gyeonghyeon-
dc.contributor.affiliatedAuthorLee, Jong Hun-
dc.type.docTypeArticle-
dc.subject.keywordAuthorbaicalein-
dc.subject.keywordAuthorantioxidants-
dc.subject.keywordAuthortight junction-
dc.subject.keywordAuthormitochondrial homeostasis-
dc.subject.keywordAuthorNrf2/NQO-1/HO-1 pathway-
dc.subject.keywordAuthorHaCaT keratinocytes-
dc.subject.keywordPlusOXIDATIVE STRESS-
dc.subject.keywordPlusHYDROGEN-PEROXIDE-
dc.subject.keywordPlusBARRIER FUNCTION-
dc.subject.keywordPlusSKIN-
dc.subject.keywordPlusPATHWAY-
dc.subject.keywordPlusDAMAGE-
dc.subject.keywordPlusCELLS-
dc.subject.keywordPlusDEGRADATION-
dc.subject.keywordPlusDYSFUNCTION-
dc.subject.keywordPlusMECHANISMS-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaFood Science & Technology-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryFood Science & Technology-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
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