Yomogin, Isolated from Artemisia iwayomogi, Inhibits Neuroinflammation Stimulated by Lipopolysaccharide via Regulating MAPK Pathway
DC Field | Value | Language |
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dc.contributor.author | Kim, Jin Hee | - |
dc.contributor.author | Ju, In Gyoung | - |
dc.contributor.author | Kim, Namkwon | - |
dc.contributor.author | Huh, Eugene | - |
dc.contributor.author | Son, So-Ri | - |
dc.contributor.author | Hong, Joon Pyo | - |
dc.contributor.author | Choi, Yujin | - |
dc.contributor.author | Jang, Dae Sik | - |
dc.contributor.author | Oh, Myung Sook | - |
dc.date.accessioned | 2023-06-27T01:40:46Z | - |
dc.date.available | 2023-06-27T01:40:46Z | - |
dc.date.created | 2023-06-27 | - |
dc.date.issued | 2023-01 | - |
dc.identifier.issn | 2076-3921 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/88239 | - |
dc.description.abstract | Neuroinflammation causes various neurological disorders, including depression and neurodegenerative diseases. Therefore, regulation of neuroinflammation is a promising therapeutic strategy for inflammation-related neurological disorders. This study aimed to investigate whether yomogin, isolated from Artemisia iwayomogi, has anti-neuroinflammatory effects. First, we evaluated the effects of yomogin by assessing pro-inflammatory mediators and cytokines in lipopolysaccharide (LPS)-stimulated BV2 microglial cells. The results showed that yomogin inhibited the increase in neuroinflammatory factors, including nitric oxide, inducible nitric oxide synthase, cyclooxygenase-2, interleukin-6, and tumor necrosis factor-alpha, and suppressed phosphorylation of c-Jun N-terminal kinase, extracellular signal-regulated kinase and p38, which participate in the mitogen-activated protein kinase (MAPK) pathway. To confirm these effects in vivo, we measured the activation of astrocyte and microglia in LPS-injected mouse brains. Results showed that yomogin treatment decreased astrocyte and microglia activations. Collectively, these results suggest that yomogin suppresses neuroinflammation by regulating the MAPK pathway and it could be a potential candidate for inflammation-mediated neurological diseases. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | ANTIOXIDANTS | - |
dc.title | Yomogin, Isolated from Artemisia iwayomogi, Inhibits Neuroinflammation Stimulated by Lipopolysaccharide via Regulating MAPK Pathway | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000916445500001 | - |
dc.identifier.doi | 10.3390/antiox12010106 | - |
dc.identifier.bibliographicCitation | ANTIOXIDANTS, v.12, no.1 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85146763716 | - |
dc.citation.title | ANTIOXIDANTS | - |
dc.citation.volume | 12 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Huh, Eugene | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | yomogin | - |
dc.subject.keywordAuthor | neuroinflammation | - |
dc.subject.keywordAuthor | p38 mitogen-activated protein kinases | - |
dc.subject.keywordAuthor | JNK mitogen-activated protein kinases | - |
dc.subject.keywordAuthor | ERK extracellular signal-regulated kinase | - |
dc.subject.keywordAuthor | Artemisia iwayomogi | - |
dc.subject.keywordPlus | NITRIC-OXIDE | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | DEPRESSION | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | INJURY | - |
dc.subject.keywordPlus | MODEL | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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