Conformal Hydrogel-Skin Coating on a Microfluidic Channel through Microstamping Transfer of the Masking Layer
- Authors
- Lee, Wonhyung; Lim, Jongkyeong; Kim, Joonwon
- Issue Date
- May-2023
- Publisher
- AMER CHEMICAL SOC
- Citation
- ANALYTICAL CHEMISTRY, v.95, no.21, pp.8332 - 8339
- Journal Title
- ANALYTICAL CHEMISTRY
- Volume
- 95
- Number
- 21
- Start Page
- 8332
- End Page
- 8339
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/88251
- DOI
- 10.1021/acs.analchem.3c00812
- ISSN
- 0003-2700
- Abstract
- Poly-(dimethylsiloxane) (PDMS) is used in microfluidicsowing toits biocompatibility and simple fabrication. However, its intrinsichydrophobicity and biofouling inhibit its microfluidic applications.Conformal hydrogel-skin coating for PDMS microchannels, involvingthe microstamping transfer of the masking layer, is reported herein.A selective uniform hydrogel layer with a thickness of similar to 1 mu mwas coated in diverse PDMS microchannels with a resolution of similar to 3 mu m, maintaining its structure and hydrophilicity after 180 days(6 months). The wettability transition of PDMS was demonstrated throughthe switched emulsification in a flow-focusing device (water-in-oil[pristine PDMS] to oil-in-water [hydrophilic PDMS]). A one-step bead-basedimmunoassay was performed to detect the anti-severe acute respiratorysyndrome coronavirus 2 IgG using a hydrogel-skin-coated point-of-careplatform.
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