IRF3 Activation in Mast Cells Promotes Fc epsilon RI-Mediated Allergic Inflammation
DC Field | Value | Language |
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dc.contributor.author | Choi, Young-Ae | - |
dc.contributor.author | Dhakal, Hima | - |
dc.contributor.author | Lee, Soyoung | - |
dc.contributor.author | Kim, Namkyung | - |
dc.contributor.author | Lee, Byungheon | - |
dc.contributor.author | Kwon, Taeg Kyu | - |
dc.contributor.author | Khang, Dongwoo | - |
dc.contributor.author | Kim, Sang-Hyun | - |
dc.date.accessioned | 2023-06-27T08:41:18Z | - |
dc.date.available | 2023-06-27T08:41:18Z | - |
dc.date.created | 2023-06-26 | - |
dc.date.issued | 2023-05 | - |
dc.identifier.issn | 2073-4409 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/88252 | - |
dc.description.abstract | (1) Background: This study aims to elucidate a novel non-transcriptional action of IRF3 in addition to its role as a transcription factor in mast cell activation and associated allergic inflammation; (2) Methods: For in vitro experiments, mouse bone-marrow-derived mast cells (mBMMCs) and a rat basophilic leukemia cell line (RBL-2H3) were used for investigating the underlying mechanism of IRF3 in mast-cell-mediated allergic inflammation. For in vivo experiments, wild-type and Irf3 knockout mice were used for evaluating IgE-mediated local and systemic anaphylaxis; (3) Results: Passive cutaneous anaphylaxis (PCA)-induced tissues showed highly increased IRF3 activity. In addition, the activation of IRF3 was observed in DNP-HSA-treated mast cells. Phosphorylated IRF3 by DNP-HSA was spatially co-localized with tryptase according to the mast cell activation process, and FceRI-mediated signaling pathways directly regulated that activity. The alteration of IRF3 affected the production of granule contents in the mast cells and the anaphylaxis responses, including PCA- and ovalbumin-induced active systemic anaphylaxis. Furthermore, IRF3 influenced the post-translational processing of histidine decarboxylase (HDC), which is required for granule maturation; and (4) Conclusion: Through this study, we demonstrated the novel function of IRF3 as an important factor inducing mast cell activation and as an upstream molecule for HDC activity. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | CELLS | - |
dc.title | IRF3 Activation in Mast Cells Promotes Fc epsilon RI-Mediated Allergic Inflammation | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 001005820000001 | - |
dc.identifier.doi | 10.3390/cells12111493 | - |
dc.identifier.bibliographicCitation | CELLS, v.12, no.11 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85161287988 | - |
dc.citation.title | CELLS | - |
dc.citation.volume | 12 | - |
dc.citation.number | 11 | - |
dc.contributor.affiliatedAuthor | Khang, Dongwoo | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | allergic inflammation | - |
dc.subject.keywordAuthor | histamine | - |
dc.subject.keywordAuthor | histidine decarboxylase | - |
dc.subject.keywordAuthor | interferon regulatory factor 3 | - |
dc.subject.keywordAuthor | mast cells | - |
dc.subject.keywordPlus | INTERFERON REGULATORY FACTOR-3 | - |
dc.subject.keywordPlus | HISTIDINE-DECARBOXYLASE | - |
dc.subject.keywordPlus | GRANULE MATURATION | - |
dc.subject.keywordPlus | HISTAMINE | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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