Urinary Phthalate Metabolites and Slow Walking Speed in the Korean Elderly Environmental Panel II Study
DC Field | Value | Language |
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dc.contributor.author | Yoon, Jeonggyo | - |
dc.contributor.author | Garcia-Esquinas, Esther | - |
dc.contributor.author | Kim, Junghoon | - |
dc.contributor.author | Kwak, Jung Hyun | - |
dc.contributor.author | Kim, Hongsoo | - |
dc.contributor.author | Kim, Sungroul | - |
dc.contributor.author | Kim, Kyoung-Nam | - |
dc.contributor.author | Hong, Yun-Chul | - |
dc.contributor.author | Choi, Yoon-Hyeong | - |
dc.date.accessioned | 2023-06-28T00:41:06Z | - |
dc.date.available | 2023-06-28T00:41:06Z | - |
dc.date.created | 2023-06-26 | - |
dc.date.issued | 2023-04 | - |
dc.identifier.issn | 0091-6765 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/88263 | - |
dc.description.abstract | BACKGROUND: Previous epidemiological studies have suggested that phthalate exposure may contribute to neurocognitive and neurobehavioral disor-ders and decreased muscle strength and bone mass, all of which may be associated with reduced physical performance. Walking speed is a reliable assessment tool for measuring physical performance in adults age 60 y and older. OBJECTIVE: We investigated associations between urinary phthalate metabolites and slowness of walking speed in community-dwelling adults ages 60-98 y.METHODS: We analyzed 1,190 older adults [range, 60-98 y of age; mean +/- standard deviation oSD thorn , 74.81 +/- 5.99] from the Korean Elderly Environmental Panel II study and measured repeatedly up to three times between 2012 and 2014. Phthalate exposure was estimated using the follow-ing phthalate metabolites in urine samples: mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP), mono -n-butyl phthalate (MnBP), mono-(2-ethyl-5-carboxypentyl) phthalate (MECPP), and mono-benzyl phthalate (MBzP). Slowness was defined as a walking speed of <1.0 meter/second. We used logistic and linear regression models to evaluate the association between each urinary phthalate metabolite and slowness or walking-speed change. We also used Bayesian kernel machine regression (BKMR) to examine overall mixture effects on walking speed.RESULTS: At enrollment, MBzP levels were associated with an increased odds of slowness [odds ratio (OR) per doubling increase: 1.15, 95% confi-dence interval (CI): 1.02, 1.30; OR for the highest vs. lowest quartile: 2.20 (95% CI: 1.12, 4.35) with p-trend across quartiles = 0.031]. In longitudinal analyses, MEHHP levels showed an increased risk of slowness [OR per doubling increase: 1.15 (95% CI: 1.02, 1.29), OR for the highest vs. lowest quartile: 1.47 (95% CI: 1.04, 2.06), p-trend = 0.035]; whereas those with higher MnBP showed a reduced risk of slowness [OR per doubling increase: 0.84 (95% CI: 0.74, 0.96), OR in the highest (vs. lowest) quartile: 0.64 (95% CI: 0.47, 0.87), p-trend = 0.006]. For linear regression models, MBzP quartiles were associated with slower walking speed (p-trend = 0.048) at enrollment, whereas MEHHP quartiles were associated with slower walking speed, and MnBP quartiles were associated with faster walking speed in longitudinal analysis (p-trend = 0.026 and <0.001, respectively). Further, the BKMR analysis revealed negative overall trends between the phthalate metabolite mixtures and walking speed and DEHP group (MEHHP, MEOHP, and MECPP) had the main effect of the overall mixture.DISCUSSION: Urinary concentrations of prevalent phthalates exhibited significant associations with slow walking speed in adults ages 60-98 y. https:// doi.org/10.1289/EHP10549 | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE | - |
dc.relation.isPartOf | ENVIRONMENTAL HEALTH PERSPECTIVES | - |
dc.title | Urinary Phthalate Metabolites and Slow Walking Speed in the Korean Elderly Environmental Panel II Study | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000974977600001 | - |
dc.identifier.doi | 10.1289/EHP10549 | - |
dc.identifier.bibliographicCitation | ENVIRONMENTAL HEALTH PERSPECTIVES, v.131, no.4 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85151793534 | - |
dc.citation.title | ENVIRONMENTAL HEALTH PERSPECTIVES | - |
dc.citation.volume | 131 | - |
dc.citation.number | 4 | - |
dc.contributor.affiliatedAuthor | Yoon, Jeonggyo | - |
dc.contributor.affiliatedAuthor | Choi, Yoon-Hyeong | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | BONE-MINERAL DENSITY | - |
dc.subject.keywordPlus | ASIAN WORKING GROUP | - |
dc.subject.keywordPlus | GAIT SPEED | - |
dc.subject.keywordPlus | DI(2-ETHYLHEXYL) PHTHALATE | - |
dc.subject.keywordPlus | TEMPORAL VARIABILITY | - |
dc.subject.keywordPlus | INFLAMMATORY MARKERS | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | NATIONAL-HEALTH | - |
dc.subject.keywordPlus | US POPULATION | - |
dc.subject.keywordPlus | HEAVY-METALS | - |
dc.relation.journalResearchArea | Environmental Sciences & Ecology | - |
dc.relation.journalResearchArea | Public, Environmental & Occupational Health | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Environmental Sciences | - |
dc.relation.journalWebOfScienceCategory | Public, Environmental & Occupational Health | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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