The Anti-Atopic Dermatitis Effects of Mentha arvensis Essential Oil Are Involved in the Inhibition of the NLRP3 Inflammasome in DNCB-Challenged Atopic Dermatitis BALB/c Mice
DC Field | Value | Language |
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dc.contributor.author | Kim, So-Yeon | - |
dc.contributor.author | Sapkota, Arjun | - |
dc.contributor.author | Bae, Young Joo | - |
dc.contributor.author | Choi, Seung-Hyuk | - |
dc.contributor.author | Bae, Ho Jung | - |
dc.contributor.author | Kim, Hyun-Jeong | - |
dc.contributor.author | Cho, Ye Eun | - |
dc.contributor.author | Choi, Yu-Yeong | - |
dc.contributor.author | An, Ju-Yeon | - |
dc.contributor.author | Cho, So-Young | - |
dc.contributor.author | Hong, Sun Hee | - |
dc.contributor.author | Choi, Ji Woong | - |
dc.contributor.author | Park, Se Jin | - |
dc.date.accessioned | 2023-07-09T02:40:44Z | - |
dc.date.available | 2023-07-09T02:40:44Z | - |
dc.date.created | 2023-07-09 | - |
dc.date.issued | 2023-04 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/88406 | - |
dc.description.abstract | The NLRP3 inflammasome is upregulated by various agents, such as nuclear factor-kappa B (NF-kappa B), lipopolysaccharide (LPS), and adenosine triphosphate (ATP). The NLRP3 inflammasome facilitations the maturation of interleukin (IL)-1 beta, a proinflammatory cytokine that is critically involved in the pathogenesis of atopic dermatitis (AD). Although the NLRP3 inflammasome clearly exacerbates AD symptoms such as erythema and pruritus, drugs for AD patients targeting the NLRP3 inflammasome are still lacking. Based on the previous findings that Mentha arvensis essential oil (MAEO) possesses strong anti-inflammatory and anti-AD properties through its inhibition of the ERK/NF-kappa B signaling pathway, we postulated that MAEO might be capable of modulating the NLRP3 inflammasome in AD. The aim of this research was to investigate whether MAEO affects the inhibition of NLRP3 inflammasome activation in murine bone marrow-derived macrophages (BMDMs) stimulated with LPS + ATP in vitro and in a murine model displaying AD-like symptoms induced by 2,4-dinitrochlorobenzene (DNCB) in vivo. We found that MAEO inhibited the expression of NLRP3 and caspase-1, leading to the suppression of NLRP3 inflammasome activation and IL-1 beta production in BMDMs stimulated with LPS + ATP. In addition, MAEO exhibited efficacy in ameliorating AD symptoms in a murine model induced by DNCB, as indicated by the reduction in dermatitis score, ear thickness, transepidermal water loss (TEWL), epidermal thickness, and immunoglobulin E (IgE) levels. Furthermore, MAEO attenuated the recruitment of NLRP3-expressing macrophages and NLRP3 inflammasome activation in murine dorsal skin lesions induced by DNCB. Overall, we provide evidence for the anti-AD effects of MAEO via inhibition of NLRP3 inflammasome activation. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.title | The Anti-Atopic Dermatitis Effects of Mentha arvensis Essential Oil Are Involved in the Inhibition of the NLRP3 Inflammasome in DNCB-Challenged Atopic Dermatitis BALB/c Mice | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000987822800001 | - |
dc.identifier.doi | 10.3390/ijms24097720 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.24, no.9 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85159298919 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.volume | 24 | - |
dc.citation.number | 9 | - |
dc.contributor.affiliatedAuthor | Sapkota, Arjun | - |
dc.contributor.affiliatedAuthor | Bae, Young Joo | - |
dc.contributor.affiliatedAuthor | Choi, Ji Woong | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Mentha arvensis | - |
dc.subject.keywordAuthor | atopic dermatitis | - |
dc.subject.keywordAuthor | NLRP3 inflammasome | - |
dc.subject.keywordAuthor | BMDMs | - |
dc.subject.keywordAuthor | IL-1 beta | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CYTOKINES | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | CHILDREN | - |
dc.subject.keywordPlus | IL-18 | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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