A Bioactive Compound-Loaded Zinc-Aminoclay Encapsulated, Pickering Emulsion System for Treating Acne-Inducing Microbes
DC Field | Value | Language |
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dc.contributor.author | Kim, Seong-Hyeon | - |
dc.contributor.author | Bae, In-Sun | - |
dc.contributor.author | Lee, Hyun Uk | - |
dc.contributor.author | Moon, Ju-Young | - |
dc.contributor.author | Lee, Young-Chul | - |
dc.date.accessioned | 2023-07-11T10:40:54Z | - |
dc.date.available | 2023-07-11T10:40:54Z | - |
dc.date.created | 2023-07-11 | - |
dc.date.issued | 2023-06 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/88455 | - |
dc.description.abstract | Acne is a common skin condition caused by the growth of certain bacteria. Many plant extracts have been investigated for their potential to combat acne-inducing microbes, and one such plant extract is microwave-assisted Opuntia humifusa extract (MA-OHE). The MA-OHE was loaded onto zinc-aminoclay (ZnAC) and encapsulated in a Pickering emulsion system (MA-OHE/ZnAC PE) to evaluate its therapeutic potential against acne-inducing microbes. Dynamic light scattering and scanning electron microscopy were used to characterize MA-OHE/ZnAC PE with a mean particle diameter of 353.97 nm and a PDI of 0.629. The antimicrobial effect of MA-OHE/ZnAC was evaluated against Staphylococcus aureus (S. aureus) and Cutibacterium acnes (C. acnes), which contribute to acne inflammation. The antibacterial activity of MA-OHE/ZnAC was 0.1 and 0.025 mg/mL to S. aureus and C. acnes, respectively, which were close to naturally derived antibiotics. Additionally, the cytotoxicity of MA-OHE, ZnAC, and MA-OHE/ZnAC was tested, and the results showed that they had no cytotoxic effects on cultured human keratinocytes in a range of 10-100 mu g/mL. Thus, MA-OHE/ZnAC is suggested to be a promising antimicrobial agent for treating acne-inducing microbes, while MA-OHE/ZnAC PE is a potentially advantageous dermal delivery system. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.title | A Bioactive Compound-Loaded Zinc-Aminoclay Encapsulated, Pickering Emulsion System for Treating Acne-Inducing Microbes | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 001003729600001 | - |
dc.identifier.doi | 10.3390/ijms24119669 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.24, no.11 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85161624730 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.volume | 24 | - |
dc.citation.number | 11 | - |
dc.contributor.affiliatedAuthor | Kim, Seong-Hyeon | - |
dc.contributor.affiliatedAuthor | Lee, Young-Chul | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Pickering emulsion | - |
dc.subject.keywordAuthor | acne | - |
dc.subject.keywordAuthor | antimicrobial | - |
dc.subject.keywordAuthor | extended release | - |
dc.subject.keywordAuthor | zinc-aminoclay (ZnAC) | - |
dc.subject.keywordAuthor | microwave-assisted Opuntia humifusa (MA-OHE) | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | KERATINOCYTES | - |
dc.subject.keywordPlus | ANTIOXIDANT | - |
dc.subject.keywordPlus | EXTRACTS | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | SKIN | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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