Anti-inflammatory and Neurotrophic 2H-1-Benzopyran Derivatives of Chaenomeles sinensis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 하영준 | - |
dc.contributor.author | 이태현 | - |
dc.contributor.author | Lalita Subedi | - |
dc.contributor.author | 김혜령 | - |
dc.contributor.author | 문규리 | - |
dc.contributor.author | 김선여 | - |
dc.contributor.author | 김충섭 | - |
dc.date.accessioned | 2023-07-20T02:41:11Z | - |
dc.date.available | 2023-07-20T02:41:11Z | - |
dc.date.created | 2023-02-17 | - |
dc.date.issued | 2022-03 | - |
dc.identifier.issn | 1226-3907 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/88539 | - |
dc.description.abstract | Two 2H-1-benzopyran derivatives, methyl 8-hydroxy-2,2-dimethyl-2H-1-benzopyran-5-carboxylate (1) and methyl 8-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-carboxylate (2), including a new compound (1) were isolated from the twigs of Chaenomeles sinensis. Their chemical structures were characterized based on analysis of NMR data including 1H and 13C, COSY, HSQC, and HMBC and HRMS data. The isolated compounds (1 and 2) were assessed for their anti-neuroinflammatory activity by measuring inhibition levels of nitric oxide (NO) production in lipopolysaccharide (LPS)-activated BV-2 cells and for their neurotrophic activity by the secretion of nerve growth factor (NGF) in C6 cells. Compounds 1 and 2 exhibited powerful anti-neuroinflammatory effects with IC50 values of 17.14 and 19.30 μM, respectively, without cell toxicity, and also showed moderate effects on the stimulation of NGF secretion levels with 113.15 ± 3.54 and 130.20 ± 8.03%, respectively. The biosynthetic pathway of 1 and 2 was proposed that they would be derived from a protocatechuic acid and an isoprenyl unit. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 한국생약학회 | - |
dc.relation.isPartOf | Natural Product Sciences | - |
dc.title | Anti-inflammatory and Neurotrophic 2H-1-Benzopyran Derivatives of Chaenomeles sinensis | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.doi | 10.20307/nps.2022.28.1.1 | - |
dc.identifier.bibliographicCitation | Natural Product Sciences, v.28, no.1, pp.1 - 5 | - |
dc.identifier.kciid | ART002828283 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85164613352 | - |
dc.citation.endPage | 5 | - |
dc.citation.startPage | 1 | - |
dc.citation.title | Natural Product Sciences | - |
dc.citation.volume | 28 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Lalita Subedi | - |
dc.contributor.affiliatedAuthor | 김선여 | - |
dc.subject.keywordAuthor | Chaenomeles sinensis | - |
dc.subject.keywordAuthor | 2H-1-benzopyran derivatives | - |
dc.subject.keywordAuthor | anti-neuroinflammation | - |
dc.subject.keywordAuthor | neurotrophic activity | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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