Effective concentration of remifentanil for successful i-gel insertion during remimazolam induction
DC Field | Value | Language |
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dc.contributor.author | Choi, Jung Ju | - |
dc.contributor.author | Jung, Wol Seon | - |
dc.contributor.author | Chang, Young Jin | - |
dc.contributor.author | Yoo, Seungbeom | - |
dc.contributor.author | Kwak, Hyun Jeong | - |
dc.date.accessioned | 2023-07-24T01:40:29Z | - |
dc.date.available | 2023-07-24T01:40:29Z | - |
dc.date.created | 2023-07-21 | - |
dc.date.issued | 2023-06 | - |
dc.identifier.issn | 2005-6419 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/88610 | - |
dc.description.abstract | Background: Remifentanil can be used as adjuvants during remimazolam induction with-out neuromuscular blockade. We evaluated the 95% effective concentration (EC) of remifentanil effect-site concentration (Ce) for the successful insertion of an i-gel using the biased-coin up-and-down method in adult patients during remimazolam induction.Methods: Forty 19-65 year-old patients scheduled to undergo surgery using i-gel were en-rolled. Anesthesia was induced using remimazolam infusion (12 mg/kg/h). Simultaneous-ly, remifentanil was infused at a predetermined Ce. After 5 min of anesthesia induction, the i-gel was inserted. The 95% EC (EC95) of remifentanil in each patient was determined using a biased-coin up-and-down method based on a successful insertion in a preceding patient. The step size of remifentanil Ce was 0.4 ng/ml. If the insertion failed, remifentanil Ce was increased in the next patient. Following successful insertions, the corresponding concentration decreased in subsequent patients with a probability of 1/19 or was main-tained with a probability of 18/19. The time from remimazolam infusion initiation to a bispectral index (BIS) < 60 (time to BIS60) and hemodynamic variables were measured and recorded.Results: The EC95 (95% CI) of Ce was 2.07 (1.94, 2.87) ng/ml. The overall time to BIS60 was 154.0 +/- 39.9 s. No patient experienced significant hypotension or bradycardia during remimazolam induction.Conclusions: The EC95 of remifentanil Ce was 2.07 (1.94, 2.87) ng/ml for successful i-gel insertion during remimazolam induction at 12 mg/kg/h without hemodynamic instability in adult patients. Future studies should measure remifentanil Ce in elderly patients or us-ing remimazolam at various infusion doses. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOC ANESTHESIOLOGISTS | - |
dc.relation.isPartOf | KOREAN JOURNAL OF ANESTHESIOLOGY | - |
dc.title | Effective concentration of remifentanil for successful i-gel insertion during remimazolam induction | - |
dc.title.alternative | 레미마졸람을 이용한 전신마취 시 i-gel 삽입을 위한 레미펜타닐의 유효 농도 | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 001009944100008 | - |
dc.identifier.doi | 10.4097/kja.22606 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF ANESTHESIOLOGY, v.76, no.3, pp.235 - 241 | - |
dc.identifier.kciid | ART002963431 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85150699237 | - |
dc.citation.endPage | 241 | - |
dc.citation.startPage | 235 | - |
dc.citation.title | KOREAN JOURNAL OF ANESTHESIOLOGY | - |
dc.citation.volume | 76 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | Choi, Jung Ju | - |
dc.contributor.affiliatedAuthor | Jung, Wol Seon | - |
dc.contributor.affiliatedAuthor | Chang, Young Jin | - |
dc.contributor.affiliatedAuthor | Yoo, Seungbeom | - |
dc.contributor.affiliatedAuthor | Kwak, Hyun Jeong | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Airway management | - |
dc.subject.keywordAuthor | General anesthesia | - |
dc.subject.keywordAuthor | Intravenous anesthetics | - |
dc.subject.keywordAuthor | Neuromus-cular blocking agents | - |
dc.subject.keywordAuthor | Remifentanil | - |
dc.subject.keywordAuthor | Remimazolam | - |
dc.subject.keywordPlus | MASK AIRWAY INSERTION | - |
dc.subject.keywordPlus | SUPRAGLOTTIC AIRWAY | - |
dc.subject.keywordPlus | PROPOFOL | - |
dc.subject.keywordPlus | ANESTHESIA | - |
dc.subject.keywordPlus | MIDAZOLAM | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.subject.keywordPlus | SAFETY | - |
dc.subject.keywordPlus | PLACEBO | - |
dc.subject.keywordPlus | DESIGN | - |
dc.relation.journalResearchArea | Anesthesiology | - |
dc.relation.journalWebOfScienceCategory | Anesthesiology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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