Systematic evaluation of antibiotic activity of a cefazolin-loaded scaffold with varying 3D printing temperatures and its application in treating osteomyelitis
DC Field | Value | Language |
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dc.contributor.author | Lee, Seung Yeon | - |
dc.contributor.author | Kim, Joo Hyun | - |
dc.contributor.author | Yi, Sun Shin | - |
dc.contributor.author | Yeo, Hyeon-Gu | - |
dc.contributor.author | Lee, Youngjeon | - |
dc.contributor.author | Hwang, Yongsung | - |
dc.contributor.author | Lee, Jin Woo | - |
dc.date.accessioned | 2023-07-24T08:41:09Z | - |
dc.date.available | 2023-07-24T08:41:09Z | - |
dc.date.issued | 2023-08 | - |
dc.identifier.issn | 1226-086X | - |
dc.identifier.issn | 1876-794X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/88632 | - |
dc.description.abstract | Osteomyelitis is one of the most common inflammatory bone diseases caused by gram-positive bacteria. Although cefazolin is widely used as an osteomyelitis antibiotic against Staphylococcus aureus, its thermo-labile properties may decrease its antibiotic activity when incorporated into bone cement, such as poly-methyl methacrylate. Thus, to fully characterize the loss of antibiotic activity during the fused deposition modeling 3D-printing processes, we systematically evaluated the antibacterial activity of a cefazolin-loaded polycaprolactone (PCL)-based scaffold at varying 3D printing temperatures against S. aureus. In vitro antibacterial activity analysis revealed that cefazolin-loaded PCL scaffolds printed between 60 degrees C and 120 degrees C could maintain the antibacterial activity, whereas the antibacterial activity of scaffolds printed between 140 degrees C and 160 degrees C was significantly decreased. In addition, the therapeutic potential of the 3D-printed, scaffolds was assessed based on serum interleukin-6 (IL-6) levels, micro-computed tomography (micro-CT), and histological evaluation using a rabbit model of S. aureus-induced chronic osteomyelitis. Our in vivo results demonstrated that the serum level of IL-6 decreased in the cefazolin-loaded PCL scaffold-transplanted group. Furthermore, micro-CT and histological analyses confirmed the decreased deformation and overgrowth of the bone. The utilization of a 3D-printable, cefazolin-loaded PCL scaffold offers a promising and distinct approach for the treatment of osteomyelitis. C 2023 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved. | - |
dc.format.extent | 11 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.title | Systematic evaluation of antibiotic activity of a cefazolin-loaded scaffold with varying 3D printing temperatures and its application in treating osteomyelitis | - |
dc.type | Article | - |
dc.identifier.wosid | 001015113700001 | - |
dc.identifier.doi | 10.1016/j.jiec.2023.05.009 | - |
dc.identifier.bibliographicCitation | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, v.124, pp 539 - 549 | - |
dc.identifier.kciid | ART002997087 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85160099396 | - |
dc.citation.endPage | 549 | - |
dc.citation.startPage | 539 | - |
dc.citation.title | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY | - |
dc.citation.volume | 124 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | Osteomyelitis | - |
dc.subject.keywordAuthor | 3D printing | - |
dc.subject.keywordAuthor | Polycaprolactone | - |
dc.subject.keywordAuthor | Cefazolin | - |
dc.subject.keywordAuthor | Antibacterial activity | - |
dc.subject.keywordPlus | STAPHYLOCOCCUS-AUREUS | - |
dc.subject.keywordPlus | BONE REGENERATION | - |
dc.subject.keywordPlus | DELIVERY-SYSTEM | - |
dc.subject.keywordPlus | MOUSE MODEL | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | OSTEOGENESIS | - |
dc.subject.keywordPlus | INFECTION | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Engineering, Chemical | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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