Chronic exposure to dexamethasone may not affect sugammadex reversal of rocuronium-induced neuromuscular blockade: an in vivo study on rats
DC Field | Value | Language |
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dc.contributor.author | Park, Ha Yeon | - |
dc.contributor.author | Choi, Hey-Ran | - |
dc.contributor.author | Kim, Yong Beom | - |
dc.contributor.author | Oh, Seok Kyeong | - |
dc.contributor.author | Kim, Taehoon | - |
dc.contributor.author | Yang, Hong Seuk | - |
dc.contributor.author | In, Junyong | - |
dc.date.accessioned | 2023-08-01T01:40:14Z | - |
dc.date.available | 2023-08-01T01:40:14Z | - |
dc.date.created | 2023-08-01 | - |
dc.date.issued | 2023-07 | - |
dc.identifier.issn | 1975-5171 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/88672 | - |
dc.description.abstract | Background: Chronic glucocorticoid exposure is associated with resistance to nondepolarizing neuromuscular blocking agents. Therefore, we hypothesized that sugammadex-induced recovery would occur more rapidly in subjects exposed to chronic dexamethasone compared to those who were not exposed. This study evaluated the sugammadex-induced recovery profile after neuromuscular blockade (NMB) in rats exposed to chronic dexamethasone.Methods: Sprague–Dawley rats were allocated to three groups (dexamethasone, control, and pair-fed group) for the in vivo study. The mice received daily intraperitoneal dexamethasone injections (500 μg/kg) or 0.9% saline for 15 days. To achieve complete NMB, 3.5 mg/kg rocuronium was administered on the sixteenth day. The recovery time to a train-of-four ratio ≥ 0.9 was measured to evaluate the complete recovery following the sugammadex injection.Results: Among the groups, no significant differences were observed in the recovery time to a train-of-four ratio ≥ 0.9 following sugammadex administration (P = 0.531). The time to the second twitch of the train-of-four recovery following rocuronium administration indicated that the duration of NMB was significantly shorter in Group D than that in Groups C and P (P = 0.001).Conclusions: Chronic exposure to dexamethasone did not shorten the recovery time of sugammadex-induced NMB reversal. However, the findings of this study indicated that no adjustments to sugammadex dosage or route of administration is required, even in patients undergoing long-term steroid treatment. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 대한마취통증의학회 | - |
dc.relation.isPartOf | Anesthesia and Pain Medicine | - |
dc.title | Chronic exposure to dexamethasone may not affect sugammadex reversal of rocuronium-induced neuromuscular blockade: an in vivo study on rats | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 2 | - |
dc.identifier.doi | 10.17085/apm.23021 | - |
dc.identifier.bibliographicCitation | Anesthesia and Pain Medicine, v.18, no.3, pp.275 - 283 | - |
dc.identifier.kciid | ART002982197 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85166663427 | - |
dc.citation.endPage | 283 | - |
dc.citation.startPage | 275 | - |
dc.citation.title | Anesthesia and Pain Medicine | - |
dc.citation.volume | 18 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | Kim, Yong Beom | - |
dc.subject.keywordAuthor | Dexamethasone | - |
dc.subject.keywordAuthor | Neuromuscular blockade | - |
dc.subject.keywordAuthor | Neuromuscular monitoring | - |
dc.subject.keywordAuthor | Rats | - |
dc.subject.keywordAuthor | Rocuronium | - |
dc.subject.keywordAuthor | Sugammadex. | - |
dc.description.journalRegisteredClass | kci | - |
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