Ecdysteroids from the Korean Endemic Species Ajuga spectabilis with Activities against Glucocorticoid Receptors and 11β-Hydroxysteroid Dehydrogenase Type 1
DC Field | Value | Language |
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dc.contributor.author | Park, InWha | - |
dc.contributor.author | Park, Keunwan | - |
dc.contributor.author | Lee, Hyeon-Seong | - |
dc.contributor.author | Hong, Seong-Min | - |
dc.contributor.author | Sriramulu, Dinesh Kumar | - |
dc.contributor.author | Hwang, Hoseong | - |
dc.contributor.author | Song, Sungmin | - |
dc.contributor.author | Baek, Jong Gwon | - |
dc.contributor.author | Kim, Dong Hoon | - |
dc.contributor.author | Kim, Sun Yeou | - |
dc.contributor.author | Kwon, Jaeyoung | - |
dc.contributor.author | Kwon, Hak Cheol | - |
dc.date.accessioned | 2023-08-07T06:40:38Z | - |
dc.date.available | 2023-08-07T06:40:38Z | - |
dc.date.created | 2023-07-23 | - |
dc.date.issued | 2023-07 | - |
dc.identifier.issn | 2470-1343 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/88700 | - |
dc.description.abstract | Two new ecdysteroids, spectasterone A (1) and spectasteroneB (2), together with four known ecdysteroids, breviflorasterone(3), ajugalactone (4), 20-hydroxyecdysone(5), and polypodine B (6) were isolatedfrom the Korean endemic plant Ajuga spectabilis using feature-based molecular networking analysis. The chemicalstructures of 1 and 2 were determined basedon the interpretation of NMR and mass spectrometric data. Their absoluteconfigurations were established using (3) J (H, H) coupling constants, NOESY interactions, Mosher'smethod, and ECD and DP4+ calculations. To identify their biologicaltarget, a machine learning-based prediction system was applied, andthe results indicated that ecdysteroids may have 11 & beta;-hydroxysteroiddehydrogenase type 1 (11 & beta;-HSD1)-related activity, which wasfurther supported by molecular docking results of ecdysteroids with11 & beta;-HSD1. Following this result, all the isolated ecdysteroidswere tested for their ability to affect the expression of 11 & beta;-hydroxysteroiddehydrogenase type 1 and glucocorticoid receptors (GRs) in HaCaT cellsirradiated with UVB. Compounds 2-5 exhibited inhibition of 11 & beta;-HSD1 expression and increasesin GR activity. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.relation.isPartOf | ACS OMEGA | - |
dc.title | Ecdysteroids from the Korean Endemic Species Ajuga spectabilis with Activities against Glucocorticoid Receptors and 11β-Hydroxysteroid Dehydrogenase Type 1 | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 001024841600001 | - |
dc.identifier.doi | 10.1021/acsomega.3c02421 | - |
dc.identifier.bibliographicCitation | ACS OMEGA, v.8, no.29, pp.26191 - 26200 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85165934432 | - |
dc.citation.endPage | 26200 | - |
dc.citation.startPage | 26191 | - |
dc.citation.title | ACS OMEGA | - |
dc.citation.volume | 8 | - |
dc.citation.number | 29 | - |
dc.contributor.affiliatedAuthor | Hong, Seong-Min | - |
dc.contributor.affiliatedAuthor | Kim, Sun Yeou | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | CONSTITUENTS | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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