Risk of breakthrough SARS-CoV-2 infection and clinical outcomes among vaccinated patients with type 2 diabetes
DC Field | Value | Language |
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dc.contributor.author | Bea, Sungho | - |
dc.contributor.author | Choi, Ahhyung | - |
dc.contributor.author | Kim, Jae Hyeon | - |
dc.contributor.author | Cho, Young Min | - |
dc.contributor.author | Choi, Won Suk | - |
dc.contributor.author | Jung, Jaehun | - |
dc.contributor.author | Shin, Ju-Young | - |
dc.date.accessioned | 2023-08-09T05:40:17Z | - |
dc.date.available | 2023-08-09T05:40:17Z | - |
dc.date.created | 2023-07-12 | - |
dc.date.issued | 2023-09 | - |
dc.identifier.issn | 1462-8902 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/88708 | - |
dc.description.abstract | AimTo explore the risk of breakthrough infection among patients with type 2 diabetes (T2D) and risk of severe clinical outcomes after SARS-CoV-2 infection according to vaccination status.Materials and MethodsWe conducted a population-based cohort study using South Korea's linked database of nationwide COVID-19 registry and claims data between 2018 and 2021. Hazard ratios (HRs) and 95% confidence intervals (CIs) for breakthrough infections were measured in 1:1 propensity-score (PS)-matched fully vaccinated patients with versus without T2D (full-vaccination cohort), and HRs for all-cause mortality, intensive care unit (ICU) admission/mechanical ventilation (MV) use, and hospitalizations after SARS-CoV-2 infection were measured in 1:1 PS-matched T2D patients with versus without full-vaccination (T2D cohort).ResultsAfter 1:1 PS matching, 2 109 970 patients with and without T2D were identified (age 63.5 years; 50.9% male). Patients with T2D showed an increased risk of breakthrough infections compared to those without T2D (HR 1.10, 95% CI 1.06-1.14). The increased risk of breakthrough infections was more notable among T2D patients receiving insulin treatment. However, the risk of severe COVID-19 outcomes was lower in fully vaccinated T2D patients compared with unvaccinated T2D patients (all-cause mortality: HR 0.54, 95% CI 0.43-0.67; ICU admission/MV use: HR 0.31, 95% CI 0.23-0.41; hospitalization: HR 0.73, 95% CI 0.68-0.78).ConclusionsWhile patients with T2D remain a vulnerable population to SARS-CoV-2 infection even after full-vaccination, full-vaccination was associated with a lower risk of adverse clinical outcomes after SARS-CoV-2 infection. These findings support the guidelines recommending patients with T2D as a priority vaccination group. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.relation.isPartOf | DIABETES OBESITY & METABOLISM | - |
dc.title | Risk of breakthrough SARS-CoV-2 infection and clinical outcomes among vaccinated patients with type 2 diabetes | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 001008557600001 | - |
dc.identifier.doi | 10.1111/dom.15163 | - |
dc.identifier.bibliographicCitation | DIABETES OBESITY & METABOLISM, v.25, no.9, pp.2734 - 2742 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85163089089 | - |
dc.citation.endPage | 2742 | - |
dc.citation.startPage | 2734 | - |
dc.citation.title | DIABETES OBESITY & METABOLISM | - |
dc.citation.volume | 25 | - |
dc.citation.number | 9 | - |
dc.contributor.affiliatedAuthor | Jung, Jaehun | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | breakthrough infection | - |
dc.subject.keywordAuthor | COVID-19 vaccine | - |
dc.subject.keywordAuthor | SARS-CoV-2 infection | - |
dc.subject.keywordAuthor | type 2 diabetes | - |
dc.subject.keywordAuthor | vaccine effectiveness | - |
dc.subject.keywordPlus | COVID-19 | - |
dc.subject.keywordPlus | HOSPITALIZATIONS | - |
dc.subject.keywordPlus | KOREA | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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