Clinicopathologic Impact of Peptide Hormonal Expression in Rectal Neuroendocrine Tumors
DC Field | Value | Language |
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dc.contributor.author | Kim, Jisup | - |
dc.contributor.author | Yang, Dong-Hoon | - |
dc.contributor.author | Jung, HaeSung | - |
dc.contributor.author | Cho, HyungJun | - |
dc.contributor.author | Jang, Hyeung-Jin | - |
dc.contributor.author | Yoo, Changhoon | - |
dc.contributor.author | Park, In Ja | - |
dc.contributor.author | Ryoo, Baek-Yeol | - |
dc.contributor.author | Ryu, Jin-Sook | - |
dc.contributor.author | Hong, Seung-Mo | - |
dc.date.accessioned | 2023-08-13T02:40:48Z | - |
dc.date.available | 2023-08-13T02:40:48Z | - |
dc.date.created | 2023-08-13 | - |
dc.date.issued | 2023-07 | - |
dc.identifier.issn | 0003-9985 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/88744 | - |
dc.description.abstract | Context.-Although several neuroendocrine cell types constitute gastroenteropancreatic neuroendocrine tumors (NETs), the clinical and prognostic implications of the expression of multiple peptide hormones have not been comprehensively evaluated in rectal NETs. Objective.-To identify the clinicopathologic characteristics and prognostic impact of peptide hormone expression.Design.-We evaluated the expression of peptide YY (PYY), glucagon, somatostatin, serotonin, insulin, and gastrin using immunolabeling in 446 endoscopically or surgically resected rectal NETs.Results.-PYY, glucagon, serotonin, somatostatin, insulin, and gastrin were expressed in 261 of 389 (67.1%), 205 of 446 (46.0%), 36 of 446 (8.1%), 33 of 446 (7.4%), 2 of 446 (0.4%), and 1 of 446 cases (0.2%), respectively. Immunoreactivity to any peptide hormone was present in 345 of 446 cases (77.4%). Tumors expressing serotonin or somatostatin were associated with lymphovascular invasion, chromogranin A expression, and shorter disease-free survival (DFS). Rectal NETs were classified as L-cell, enterochromaffin-cell, D-cell, null-expression, or mixed -expression type based on peptide hormonal expression status. Patients with D-cell NET had the shortest DFS (10 -year DFS, 54.5%), followed by those with enterochromaffin-cell NET (89.5%), null expression (97.0%),L-cell NET (99.6%), and mixed-expression NET (100%; P , .001). Multivariable analyses revealed that somatostatin expres-sion was an independent indicator of poor prognosis with respect to DFS in rectal NETs (P = .001).Conclusions.-Somatostatin expression is a poor prognostic indicator in patients with rectal NETs. Therefore, additional peptide hormonal immunolabeling, including somatostatin, serotonin, and PYY, in rectal NETs can provide more information regarding DFS. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | COLL AMER PATHOLOGISTS | - |
dc.relation.isPartOf | ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE | - |
dc.title | Clinicopathologic Impact of Peptide Hormonal Expression in Rectal Neuroendocrine Tumors | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 001025669300006 | - |
dc.identifier.doi | 10.5858/arpa.2022-0032-OA | - |
dc.identifier.bibliographicCitation | ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE, v.147, no.7, pp.797 - 807 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85164233644 | - |
dc.citation.endPage | 807 | - |
dc.citation.startPage | 797 | - |
dc.citation.title | ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE | - |
dc.citation.volume | 147 | - |
dc.citation.number | 7 | - |
dc.contributor.affiliatedAuthor | Kim, Jisup | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | AGGRESSIVE CLINICAL BEHAVIOR | - |
dc.subject.keywordPlus | DUODENAL CARCINOIDS | - |
dc.subject.keywordPlus | CELL TUMORS | - |
dc.subject.keywordPlus | PANCREAS | - |
dc.subject.keywordPlus | NEUROFIBROMATOSIS | - |
dc.relation.journalResearchArea | Medical Laboratory Technology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalResearchArea | Pathology | - |
dc.relation.journalWebOfScienceCategory | Medical Laboratory Technology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.relation.journalWebOfScienceCategory | Pathology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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