6-Shogaol, an Active Ingredient of Ginger, Improves Intestinal and Brain Abnormalities in Proteus Mirabilis-Induced Parkinson's Disease Mouse Model
DC Field | Value | Language |
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dc.contributor.author | Huh, Eugene | - |
dc.contributor.author | Choi, Jin Gyu | - |
dc.contributor.author | Choi, Yujin | - |
dc.contributor.author | Ju, In Gyoung | - |
dc.contributor.author | Noh, Dongjin | - |
dc.contributor.author | Shin, Dong-yun | - |
dc.contributor.author | Kim, Dong Hyun | - |
dc.contributor.author | Park, Hi-Joon | - |
dc.contributor.author | Oh, Myung Sook | - |
dc.date.accessioned | 2023-08-13T02:40:54Z | - |
dc.date.available | 2023-08-13T02:40:54Z | - |
dc.date.issued | 2023-07 | - |
dc.identifier.issn | 1976-9148 | - |
dc.identifier.issn | 2005-4483 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/88745 | - |
dc.description.abstract | Parkinson's disease (PD) which has various pathological mechanisms, recently, it is attracting attention to the mechanism via microbiome-gut-brain axis. 6-Shogaol, a representative compound of ginger, have been known for improving PD phenotypes by reducing neuroinflammatory responses. In the present study, we investigated whether 6-shogaol and ginger attenuate degenera-tion induced by Proteus mirabilis (P. mirabilis) on the intestine and brain, simultaneously. C57BL/6J mice received P. mirabilis for 5 days. Ginger (300 mg/kg) and 6-shogaol (10 mg/kg) were treated by gavage feeding for 22 days including the period of P. mirabilis treatment. Results showed that 6-shogaol and ginger improved motor dysfunction and dopaminergic neuronal death induced by P. mirabilis treatment. In addition, they suppressed P. mirabilis-induced intestinal barrier disruption, pro-inflammatory signals such as toll-like receptor and TNF-& alpha;, and intestinal & alpha;-synuclein aggregation. Moreover, ginger and 6-shogaol significantly inhibited neu-roinflammation and & alpha;-synuclein in the brain. Taken together, 6-shogaol and ginger have the potential to ameliorate PD-like motor behavior and degeneration of dopaminergic neurons induced by P. mirabilis in mice. Here, these findings are meaningful in that they provide the first experimental evidence that 6-shogaol might attenuate PD via regulating gut-brain axis. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN SOC APPLIED PHARMACOLOGY | - |
dc.title | 6-Shogaol, an Active Ingredient of Ginger, Improves Intestinal and Brain Abnormalities in Proteus Mirabilis-Induced Parkinson's Disease Mouse Model | - |
dc.type | Article | - |
dc.identifier.wosid | 001031546800001 | - |
dc.identifier.doi | 10.4062/biomolther.2023.098 | - |
dc.identifier.bibliographicCitation | BIOMOLECULES & THERAPEUTICS, v.31, no.4, pp 417 - 424 | - |
dc.identifier.kciid | ART002968699 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85167847026 | - |
dc.citation.endPage | 424 | - |
dc.citation.startPage | 417 | - |
dc.citation.title | BIOMOLECULES & THERAPEUTICS | - |
dc.citation.volume | 31 | - |
dc.citation.number | 4 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Parkinson's disease | - |
dc.subject.keywordAuthor | Microbiota-Gut-Brain axis | - |
dc.subject.keywordAuthor | 6-shogaol | - |
dc.subject.keywordAuthor | ginger | - |
dc.subject.keywordAuthor | Proteus mirabilis | - |
dc.subject.keywordPlus | GUT MICROBIOTA | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | NEUROINFLAMMATION | - |
dc.subject.keywordPlus | CONSTITUENT | - |
dc.subject.keywordPlus | DEFICITS | - |
dc.subject.keywordPlus | BARRIER | - |
dc.subject.keywordPlus | ENZYMES | - |
dc.subject.keywordPlus | CELLS | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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