Comparable humoral and cellular immunity against Omicron variant BA.4/5 of once-boosted BA.1/2 convalescents and twice-boosted COVID-19-naïve individuals
DC Field | Value | Language |
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dc.contributor.author | Kang, Chang Kyung | - |
dc.contributor.author | Kim, Min-Gang | - |
dc.contributor.author | Park, Seong-wook | - |
dc.contributor.author | Kim, Yong-Woo | - |
dc.contributor.author | Lee, Chan Mi | - |
dc.contributor.author | Choe, Pyoeng Gyun | - |
dc.contributor.author | Park, Wan Beom | - |
dc.contributor.author | Kim, Nam Joong | - |
dc.contributor.author | Kim, Minji | - |
dc.contributor.author | Lee, Soojin | - |
dc.contributor.author | Kim, Ik Soo | - |
dc.contributor.author | Lee, Chang-Han | - |
dc.contributor.author | Shin, Hyun Mu | - |
dc.contributor.author | Kim, Hang-Rae | - |
dc.contributor.author | Oh, Myoung-don | - |
dc.date.accessioned | 2023-08-19T06:41:24Z | - |
dc.date.available | 2023-08-19T06:41:24Z | - |
dc.date.issued | 2023-02 | - |
dc.identifier.issn | 0146-6615 | - |
dc.identifier.issn | 1096-9071 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/88784 | - |
dc.description.abstract | The fourth vaccination dose confers additional protective immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in individuals with no prior coronavirus disease-19 (COVID-19). However, its immunological benefit against currently circulating BA.4/5 is unclear in individuals who have received a booster shot and been infected with Omicron variant BA.1/2. We analyzed immune responses in whom had been boosted once and did not have COVID-19 (n = 16), boosted once and had COVID-19 when BA.1/2 was dominant in Korea (Hybrid-6M group, n = 27), and boosted twice and did not have COVID-19 (Vx4 group, n = 15). Antibody binding activities against RBDo BA.1 and RBDo BA.4/5, antigen-specific memory CD4+ and CD8+ T-cell responses against BA.4/5, and B-cell responses against SARS-CoV-2 wild-type did not differ statistically between the Hybrid-6M and Vx4 groups. The humoral and cellular immune responses of the Hybrid-6M group against BA.4/5 were comparable to those of the Vx4 group. Individuals who had been boosted and had an Omicron infection in early 2022 may not have high priority for an additional vaccination. © 2023 Wiley Periodicals LLC. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | WILEY | - |
dc.title | Comparable humoral and cellular immunity against Omicron variant BA.4/5 of once-boosted BA.1/2 convalescents and twice-boosted COVID-19-naïve individuals | - |
dc.type | Article | - |
dc.identifier.wosid | 001034949300020 | - |
dc.identifier.doi | 10.1002/jmv.28558 | - |
dc.identifier.bibliographicCitation | Journal of Medical Virology, v.95, no.2 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85148651877 | - |
dc.citation.title | Journal of Medical Virology | - |
dc.citation.volume | 95 | - |
dc.citation.number | 2 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | COVID-19 | - |
dc.subject.keywordAuthor | hybrid immunity | - |
dc.subject.keywordAuthor | Omicron variant | - |
dc.subject.keywordAuthor | SARS-CoV-2 | - |
dc.subject.keywordAuthor | vaccination | - |
dc.relation.journalResearchArea | Virology | - |
dc.relation.journalWebOfScienceCategory | Virology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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