Effects of CYP3A4*22 polymorphism on trough concentration of tacrolimus in kidney transplantation: a systematic review and meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Kim, Jung Sun | - |
dc.contributor.author | Shim, Sunyoung | - |
dc.contributor.author | Yee, Jeong | - |
dc.contributor.author | Choi, Kyung Hee | - |
dc.contributor.author | Gwak, Hye Sun | - |
dc.date.accessioned | 2023-08-25T08:41:25Z | - |
dc.date.available | 2023-08-25T08:41:25Z | - |
dc.date.created | 2023-08-25 | - |
dc.date.issued | 2023-07 | - |
dc.identifier.issn | 1663-9812 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/88849 | - |
dc.description.abstract | Purpose: Tacrolimus (Tac) is a widely used immunosuppressive agent in kidney transplantation. Cytochrome P450 (CYP), especially CYP3A4 enzymes are responsible for the metabolism of drugs. However, the correlation between plasma Tac concentration and CYP3A4*22 gene variants is controversial. This meta-analysis aims to evaluate the association between CYP3A4*22 polymorphism and the dose-adjusted trough concentration (C-0/D) of Tac in adult kidney transplant patients.Methods: We conducted a literature review for qualifying studies using the PubMed, Web of Science, and Embase databases until July 2023. For the continuous variables (C-0/D and daily dose), mean difference (MD) and corresponding 95% confidence intervals (CIs) were calculated to evaluate the association between the CYP3A4 ( * ) 22 and Tac pharmacokinetics. We performed an additional analysis on the relationship of CYP3A5*3 with Tac PKs and analyzed the effects of CYP3A4*22 in CYP3A5 non-expressers.Results: Overall, eight eligible studies with 2,683 renal transplant recipients were included in this meta-analysis. The CYP3A4*22 allele was significantly associated with a higher C-0/D (MD 0.57 ng/mL/mg (95% CI: 0.28 to 0.86; p = 0.0001) and lower mean daily dose requirement (MD -2.02 mg/day, 95% CI: -2.55 to -1.50; p < 0.00001). An additional meta-analysis demonstrated that carrying the CYP3A5*3 polymorphism greatly impacted Tac blood concentration. From the result with CYP3A5 non-expressers, CYP3A4*22 showed significant effects on the Tac C-0/D and dose requirement even after adjusting the effect of CYP3A5*3.Conclusion: Patients with CYP3A4*22 allele showed significantly higher plasma C-0/D of Tac and required lower daily dose to achieve the therapeutic trough level after kidney transplantation. These findings of our meta-analysis may provide further evidence for the effects of genetic polymorphism in CYP3A4 on the PKs of Tac, which will improve individualized treatment in a clinical setting. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | FRONTIERS MEDIA SA | - |
dc.relation.isPartOf | FRONTIERS IN PHARMACOLOGY | - |
dc.title | Effects of CYP3A4*22 polymorphism on trough concentration of tacrolimus in kidney transplantation: a systematic review and meta-analysis | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 001044529700001 | - |
dc.identifier.doi | 10.3389/fphar.2023.1201083 | - |
dc.identifier.bibliographicCitation | FRONTIERS IN PHARMACOLOGY, v.14 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85167423938 | - |
dc.citation.title | FRONTIERS IN PHARMACOLOGY | - |
dc.citation.volume | 14 | - |
dc.contributor.affiliatedAuthor | Choi, Kyung Hee | - |
dc.type.docType | Review | - |
dc.subject.keywordAuthor | tacrolimus | - |
dc.subject.keywordAuthor | CYP3A4*22 | - |
dc.subject.keywordAuthor | polymorphism | - |
dc.subject.keywordAuthor | trough concentration | - |
dc.subject.keywordAuthor | kidney transplantation | - |
dc.subject.keywordPlus | SINGLE-NUCLEOTIDE POLYMORPHISMS | - |
dc.subject.keywordPlus | DOSE REQUIREMENTS | - |
dc.subject.keywordPlus | CLINICAL PHARMACOKINETICS | - |
dc.subject.keywordPlus | GENETIC-VARIANTS | - |
dc.subject.keywordPlus | CYP3A5 | - |
dc.subject.keywordPlus | CYP3A4-ASTERISK-22 | - |
dc.subject.keywordPlus | PHARMACOGENETICS | - |
dc.subject.keywordPlus | EXPOSURE | - |
dc.subject.keywordPlus | PHARMACODYNAMICS | - |
dc.subject.keywordPlus | CYCLOSPORINE | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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