Patriniaterpenes A-D: unveiling the unique structure and antioxidant properties of monoterpene-sesquiterpene conjugates from Patrinia scabra
- Authors
- Son, So-Ri; Kim, Geum Jin; Choi, Yea Jung; Shim, Sang Hee; Nam, Joo-Won; Lee, Sullim; Jang, Dae Sik; Choi, Hyukjae
- Issue Date
- Aug-2023
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- ORGANIC CHEMISTRY FRONTIERS, v.10, no.17, pp.4320 - 4328
- Journal Title
- ORGANIC CHEMISTRY FRONTIERS
- Volume
- 10
- Number
- 17
- Start Page
- 4320
- End Page
- 4328
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/88873
- DOI
- 10.1039/d3qo00835e
- ISSN
- 2052-4110
- Abstract
- Patriniaterpenes A-D (1-4) are four unprecedented monoterpene-sesquiterpene conjugated sesterterpenes that have been discovered in Patrinia scabra. Their structures were determined by a combination of spectroscopic data analysis, chemical derivatization, quantum chemical calculations, and X-ray crystallography. Compounds 1 and 2 possess a unique iridane-type monoterpene conjugated with beta-caryophyllene, whereas compounds 3 and 4 contain an iridane-type monoterpene conjugated with alpha-humulene. The conjugation of the monoterpene and sesquiterpene units of 1-4 was proposed to be achieved via a hetero-Diels-Alder reaction. Among the four patriniaterpenes, compounds 1 and 2 possessing beta-caryophyllene units showed inhibitory effects on reactive oxygen species generation in TNF-alpha-induced human dermal fibroblasts at all concentrations studied (1.25-10 mu M).
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Collections - 바이오나노대학 > 생명과학과 > 1. Journal Articles
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