Risk Assessment Considering the Bioavailability of 3-β-d-Glucosides of Deoxynivalenol and Nivalenol through Food Intake in Korea
DC Field | Value | Language |
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dc.contributor.author | Lee, Sang Yoo | - |
dc.contributor.author | Cho, Solyi | - |
dc.contributor.author | Woo, So Young | - |
dc.contributor.author | Hwang, Myungsil | - |
dc.contributor.author | Chun, Hyang Sook | - |
dc.date.accessioned | 2023-08-28T00:42:11Z | - |
dc.date.available | 2023-08-28T00:42:11Z | - |
dc.date.created | 2023-08-25 | - |
dc.date.issued | 2023-07 | - |
dc.identifier.issn | 2072-6651 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/88891 | - |
dc.description.abstract | Deoxynivalenol and nivalenol are major type B trichothecenes and the most frequently occurring mycotoxins worldwide. Their 3-& beta;-d-glucoside forms have recently become a safety management issue. These glucoside conjugates are converted back to the parent toxins during human digestion, but studies to confirm their bioavailability are lacking. In this study, a risk assessment was performed considering the bioavailability of glucoside conjugates. A literature review was conducted to compile the existing bioavailability studies of glucoside conjugates, and three exposure scenarios considering bioavailability were established. As a result of a risk assessment using deterministic and probabilistic methods, both the deoxynivalenol and nivalenol groups had safe levels of tolerable daily intake percentage (TDI%), not exceeding 100%. The TDI% for the nivalenol group was approximately 2-3 times higher than that for the deoxynivalenol group. Notably, infants showed higher TDI% than adults for both toxin groups. By food processing type, the overall TDI% was highest for raw material, followed by simple-processed and then fermented-processed. Since glucoside conjugates can be converted into parent toxins during the digestion process, a risk assessment considering bioavailability allows the more accurate evaluation of the risk level of glucoside conjugates and can direct their safety management in the future. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | TOXINS | - |
dc.title | Risk Assessment Considering the Bioavailability of 3-β-d-Glucosides of Deoxynivalenol and Nivalenol through Food Intake in Korea | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 001037628400001 | - |
dc.identifier.doi | 10.3390/toxins15070460 | - |
dc.identifier.bibliographicCitation | TOXINS, v.15, no.7 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85165869251 | - |
dc.citation.title | TOXINS | - |
dc.citation.volume | 15 | - |
dc.citation.number | 7 | - |
dc.contributor.affiliatedAuthor | Hwang, Myungsil | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | type B trichothecene | - |
dc.subject.keywordAuthor | modified mycotoxin | - |
dc.subject.keywordAuthor | exposure | - |
dc.subject.keywordAuthor | glucoside conjugate | - |
dc.subject.keywordPlus | MASKED MYCOTOXIN DEOXYNIVALENOL-3-GLUCOSIDE | - |
dc.subject.keywordPlus | EXPOSURE | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | TOXICITY | - |
dc.subject.keywordPlus | SYSTEMS | - |
dc.subject.keywordPlus | IMMUNE | - |
dc.subject.keywordPlus | WHEAT | - |
dc.subject.keywordPlus | RICE | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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