The Prognostic Significance of Leukocyte Count on All-Cause and Cardiovascular Disease Mortality: A Systematic Review and Meta-Analysis
DC Field | Value | Language |
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dc.contributor.author | Park, Cheri | - |
dc.contributor.author | Yoo, Kanghee | - |
dc.contributor.author | Lee, Soohyun | - |
dc.contributor.author | Kim, Hyerin | - |
dc.contributor.author | Son, Eunjeong | - |
dc.contributor.author | Lee, Dongjun | - |
dc.contributor.author | Ko, Dai Sik | - |
dc.contributor.author | Kim, Kihun | - |
dc.contributor.author | Kim, Yun Hak | - |
dc.date.accessioned | 2023-08-30T00:40:16Z | - |
dc.date.available | 2023-08-30T00:40:16Z | - |
dc.date.created | 2023-08-30 | - |
dc.date.issued | 2023-09 | - |
dc.identifier.issn | 0002-9149 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/89005 | - |
dc.description.abstract | White blood cells (WBCs) act as mediators of inflammatory responses and are commonly measured in hospitals. Although several studies have reported a relation between WBC count and mortality, no systematic review or meta-analysis has been conducted. This study aimed to identify an association between WBC count and mortality. We conducted a systematic search on Embase using keywords such as "white blood cell" and "mortality." We analyzed the hazard ratios (HRs) for WBC count of 1.0 & POUND; 109 cells/L regarding 2 crite-ria: the cause of mortality and the follow-up period. A total of 13 of 222 articles comprising a total of 62,904 participants were included in this study, meeting the criteria set. A positive association was observed between WBC count and mortality, as indicated by an HR of 1.10 (95% confidence interval [CI] 1.08 to 1.13). In additionally, WBC count emerged as a signif-icant predictor of mortality in both groups, with an HR of 1.10 (95% CI 1.07 to 1.12) for patients with cardiovascular disease and an HR of 1.12 (95% CI 1.07 to 1.17) for the general population or patients with COVID-19. Furthermore, a higher WBC count demonstrated a significant association with long-term all-cause mortality (HR 1.09, 95% CI 1.07 to 1.12) and long-term cardiovascular mortality (HR 1.05, 95% CI 1.02 to 1.07). Similarly, a signifi-cant association was found between higher WBC count and short-term all-cause mortality (HR 1.12, 95% CI 1.09 to 1.16) and cardiovascular mortality (HR 1.12, 95% CI 1.07 to 1.17). Further research is necessary to explore the relation between WBC count and disease progression or death and to establish causality between elevated WBC count and disease progression. & COPY; 2023 Elsevier Inc. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC | - |
dc.relation.isPartOf | AMERICAN JOURNAL OF CARDIOLOGY | - |
dc.title | The Prognostic Significance of Leukocyte Count on All-Cause and Cardiovascular Disease Mortality: A Systematic Review and Meta-Analysis | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 001050675400001 | - |
dc.identifier.doi | 10.1016/j.amjcard.2023.06.119 | - |
dc.identifier.bibliographicCitation | AMERICAN JOURNAL OF CARDIOLOGY, v.203, pp.226 - 233 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85165684476 | - |
dc.citation.endPage | 233 | - |
dc.citation.startPage | 226 | - |
dc.citation.title | AMERICAN JOURNAL OF CARDIOLOGY | - |
dc.citation.volume | 203 | - |
dc.contributor.affiliatedAuthor | Ko, Dai Sik | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | BLOOD-CELL COUNT | - |
dc.subject.keywordPlus | CORONARY-HEART-DISEASE | - |
dc.subject.keywordPlus | C-REACTIVE PROTEIN | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | FIBRINOGEN | - |
dc.subject.keywordPlus | PREDICTOR | - |
dc.subject.keywordPlus | REVASCULARIZATION | - |
dc.subject.keywordPlus | INTERVENTION | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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