Detailed Information

Cited 6 time in webofscience Cited 6 time in scopus
Metadata Downloads

Exosome membrane-sheathed and multi-stimuli-responsive MnO2 nanoparticles with self-oxygenation and energy depletion abilities potentiate the sonodynamic therapy of hypoxic tumors

Authors
Hoang, Quan TruongCao, Thuy Giang NguyenKang, Su JinLee, MinjongKang, Ji HeePark, Hyun SuKim, Jong-EunBhang, Suk HoKo, Young TagRhee, Won JongShim, Min Suk
Issue Date
Sep-2023
Publisher
ELSEVIER SCIENCE SA
Keywords
Sonodynamic therapy; Hollow MnO 2; Exosome membrane; Glycolysis inhibition; Hypoxia
Citation
CHEMICAL ENGINEERING JOURNAL, v.472
Journal Title
CHEMICAL ENGINEERING JOURNAL
Volume
472
URI
https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/89011
DOI
10.1016/j.cej.2023.144871
ISSN
1385-8947
Abstract
Sonodynamic therapy (SDT), which employs ultrasound (US) to activate sonosensitizers to generate reactive oxygen species (ROS), has emerged as an effective approach for treating deep-seated tumors. However, poor biocompatibility of sonosensitizers and hypoxic tumor microenvironments are significant challenges for in vivo SDT. Herein, hollow manganese dioxide nanoparticles (MnO2 NPs) encapsulating the sonosensitizer, indocyanine green (ICG), were developed for enhanced sonodynamic cancer therapy by high ICG loading and tumor hypoxia relief. A glycolysis inhibitor, FX11, was co-loaded into MnO2 NPs to boost SDT efficacy via FX11-induced energy depletion. Because of the high biocompatibility, low immunogenicity, and efficient intracellular delivery of exosomes, ICG- and FX11-loaded MnO2 NP [M(ICG/FX11)] was coated with exosome membranes for safe and efficient in vivo SDT. The exosome membrane-coated M(ICG/FX11) [Exo-M(ICG/FX11)] exhibited triple pH/ H2O2/US-responsive drug release while avoiding premature drug leakage. Exo-M(ICG/FX11) was efficiently internalized by MCF-7 human breast cancer cells and catalyzed the endogenous H2O2 to generate O2 to relieve tumor hypoxia. Consequently, Exo-M(ICG/FX11) markedly boosted intracellular ROS levels upon US irradiation. Moreover, Exo-M(ICG/FX11) effectively inhibited glycolytic pathways, thereby potentiating the anticancer efficacy of SDT. An in vivo study using tumor-xenografted mice demonstrated that Exo-M(ICG/FX11) effectively accumulated in tumors and alleviated tumor hypoxia. Notably, Exo-M(ICG/FX11) combined with US substantially suppressed tumors in mice without causing systemic toxicity, owing to the synergistic effect of O2 suppliedSDT and energy-depleting chemotherapy. This study demonstrates that biomimetic Exo-M(ICG/FX11) is a safe and efficient nanoplatform for the treatment of hypoxic tumors.
Files in This Item
There are no files associated with this item.
Appears in
Collections
약학대학 > 약학과 > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Ko, Young Tag photo

Ko, Young Tag
Pharmacy (Dept.of Pharmacy)
Read more

Altmetrics

Total Views & Downloads

BROWSE