Liver transplantation for combined hepatocellular carcinoma and cholangiocarcinoma: A multicenter study
DC Field | Value | Language |
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dc.contributor.author | Kim, Jongman | - |
dc.contributor.author | Joo, Dong-Jin | - |
dc.contributor.author | Hwang, Shin | - |
dc.contributor.author | Lee, Jeong-Moo | - |
dc.contributor.author | Ryu, Je-Ho | - |
dc.contributor.author | Nah, Yang-Won | - |
dc.contributor.author | Kim, Dong-Sik | - |
dc.contributor.author | Kim, Doo-Jin | - |
dc.contributor.author | You, Young-Kyoung | - |
dc.contributor.author | Yu, Hee-Chul | - |
dc.date.accessioned | 2023-09-02T03:40:31Z | - |
dc.date.available | 2023-09-02T03:40:31Z | - |
dc.date.created | 2023-08-29 | - |
dc.date.issued | 2023-07 | - |
dc.identifier.issn | 1948-9366 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/89026 | - |
dc.description.abstract | BACKGROUNDPatients with combined hepatocellular carcinoma and cholangiocarcinoma (cHCC-CC) are not traditionally considered eligible for liver transplantation (LT) due to poor outcomes.AIMTo compare outcomes between living donor LT (LDLT) patients with hepatocellular carcinoma (HCC) and LT patients with cHCC-CC and to identify risk factors for tumor recurrence and death after LT in cHCC-CC patients.METHODSData for pathologically diagnosed cHCC-CC patients (n = 111) who underwent LT from 2000 to 2018 were collected for a nine-center retrospective review. Patients (n = 141) who received LDLT for HCC at Samsung Medical Center from January 2013 to March 2017 were selected as the control group. Seventy patients in two groups, respectively, were selected by 1:1 matching.RESULTSCumulative disease-free survival (DFS) and overall survival (OS) in the cHCC-CC group were significantly worse than in the HCC group both before and after matching. Extrahepatic recurrence incidence in the cHCC-CC group was higher than that in the HCC group (75.5% vs 33.3%, P < 0.001). Multivariate analysis demonstrated that the cHCC-CC group had significantly higher rates of tumor recurrence and death compared to the HCC group. In cHCC-CC subgroup analysis, frequency of locoregional therapies > 3, tumor size > 3 cm, and lymph node metastasis were predisposing factors for tumor recurrence in multivariate analysis. Only a maximum tumor size > 3 cm was a predisposing factor for death.CONCLUSIONThe poor prognosis of patients diagnosed with cHCC-CC after LT can be predicted based on the explanted liver. Frequent regular surveillance for cHCC-CC patients should be required for early detection of tumor recurrence. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | BAISHIDENG PUBLISHING GROUP INC | - |
dc.relation.isPartOf | WORLD JOURNAL OF GASTROINTESTINAL SURGERY | - |
dc.title | Liver transplantation for combined hepatocellular carcinoma and cholangiocarcinoma: A multicenter study | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 001046814000008 | - |
dc.identifier.doi | 10.4240/wjgs.v15.i7.1340 | - |
dc.identifier.bibliographicCitation | WORLD JOURNAL OF GASTROINTESTINAL SURGERY, v.15, no.7, pp.1340 - 1353 | - |
dc.description.isOpenAccess | Y | - |
dc.citation.endPage | 1353 | - |
dc.citation.startPage | 1340 | - |
dc.citation.title | WORLD JOURNAL OF GASTROINTESTINAL SURGERY | - |
dc.citation.volume | 15 | - |
dc.citation.number | 7 | - |
dc.contributor.affiliatedAuthor | Kim, Doo-Jin | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Liver transplantation | - |
dc.subject.keywordAuthor | Outcomes | - |
dc.subject.keywordAuthor | Intrahepatic cholangiocarcinoma | - |
dc.subject.keywordAuthor | Hepatocellular carcinoma | - |
dc.subject.keywordAuthor | Recurrence | - |
dc.subject.keywordPlus | LONG-TERM PROGNOSIS | - |
dc.subject.keywordPlus | INTRAHEPATIC CHOLANGIOCARCINOMA | - |
dc.subject.keywordPlus | CLASSIFICATION | - |
dc.subject.keywordPlus | RESECTION | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.description.journalRegisteredClass | scie | - |
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