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Clinical investigation of botulinum toxin (prabotulinumtoxin A) for bruxism related to masseter muscle hypertrophy: A prospective study

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dc.contributor.authorJung, Bok Ki-
dc.contributor.authorPark, Hojin-
dc.contributor.authorCheon, Young Woo-
dc.contributor.authorYun, In Sik-
dc.contributor.authorChoi, Jong-Woo-
dc.contributor.authorKim, Han Jo-
dc.contributor.authorLee, Mu Young-
dc.contributor.authorKang, Byeong Su-
dc.contributor.authorKang, Tae Jo-
dc.date.accessioned2023-09-02T13:40:42Z-
dc.date.available2023-09-02T13:40:42Z-
dc.date.created2023-08-29-
dc.date.issued2023-05-
dc.identifier.issn1010-5182-
dc.identifier.urihttps://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/89037-
dc.description.abstractThis study aims to confirm the effectiveness and safety of a prabotulinumtoxin type A (praBTX-A) injection in patients with bruxism and masseter hypertrophy. The study included patients who ground or clenched their teeth while sleeping and had computed tomography (CT) scans that showed a maximum thickness of the masseter muscle of 15 mm or more. The praBTX-A was administered bilaterally into the masseter muscles; 15 U/side for group 1, 25 U/side for group 2, and 35 U/side for group 3. CT scans and bruxism questionnaires were conducted before and eight weeks after the injection. Thirty-seven patients were enrolled, but three dropped out due to loss of follow-up. After injection, masseter thickness decreased to 15.1 & PLUSMN; 2.0 mm for group 1, 14.3 & PLUSMN; 2.9 mm for group 2, and 13.4 & PLUSMN; 1.8 mm for group 3 (p = 0.043). Group 3 showed a statistically significant lower masseter thickness compared to group 1 (p = 0.039). Both subjective and objective frequencies of bruxism decreased for all groups, but there were no significant differences in either subjective (p = 0.396) or objective frequencies (p = 0.87) between the groups after the injection. The results of this study suggest that praBTX-A injection is a safe and effective treatment for bruxism and masseter hypertrophy. A dosage of 35 IU/side can effectively decrease masseter thickness and relieve bruxism symptoms. Even the minimum dosage of 15 IU/side can contribute to improvements in bruxism symptoms. This investigation provides valuable information for managing bruxism that is associated with hypertrophic masseter muscles. & COPY; 2023 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.-
dc.language영어-
dc.language.isoen-
dc.publisherCHURCHILL LIVINGSTONE-
dc.relation.isPartOfJOURNAL OF CRANIO-MAXILLOFACIAL SURGERY-
dc.titleClinical investigation of botulinum toxin (prabotulinumtoxin A) for bruxism related to masseter muscle hypertrophy: A prospective study-
dc.typeArticle-
dc.type.rimsART-
dc.description.journalClass1-
dc.identifier.wosid001049916200001-
dc.identifier.doi10.1016/j.jcms.2023.05.005-
dc.identifier.bibliographicCitationJOURNAL OF CRANIO-MAXILLOFACIAL SURGERY, v.51, no.5, pp.332 - 337-
dc.description.isOpenAccessN-
dc.identifier.scopusid2-s2.0-85164431159-
dc.citation.endPage337-
dc.citation.startPage332-
dc.citation.titleJOURNAL OF CRANIO-MAXILLOFACIAL SURGERY-
dc.citation.volume51-
dc.citation.number5-
dc.contributor.affiliatedAuthorCheon, Young Woo-
dc.type.docTypeArticle-
dc.subject.keywordAuthorBotulinum toxins-
dc.subject.keywordAuthorBruxism-
dc.subject.keywordAuthorMasseter muscle-
dc.subject.keywordPlusDOUBLE-BLIND-
dc.subject.keywordPlusEFFICACY-
dc.subject.keywordPlusMODERATE-
dc.subject.keywordPlusSAFETY-
dc.subject.keywordPlusPAIN-
dc.relation.journalResearchAreaDentistry, Oral Surgery & Medicine-
dc.relation.journalResearchAreaSurgery-
dc.relation.journalWebOfScienceCategoryDentistry, Oral Surgery & Medicine-
dc.relation.journalWebOfScienceCategorySurgery-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
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