Clinical investigation of botulinum toxin (prabotulinumtoxin A) for bruxism related to masseter muscle hypertrophy: A prospective study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jung, Bok Ki | - |
dc.contributor.author | Park, Hojin | - |
dc.contributor.author | Cheon, Young Woo | - |
dc.contributor.author | Yun, In Sik | - |
dc.contributor.author | Choi, Jong-Woo | - |
dc.contributor.author | Kim, Han Jo | - |
dc.contributor.author | Lee, Mu Young | - |
dc.contributor.author | Kang, Byeong Su | - |
dc.contributor.author | Kang, Tae Jo | - |
dc.date.accessioned | 2023-09-02T13:40:42Z | - |
dc.date.available | 2023-09-02T13:40:42Z | - |
dc.date.created | 2023-08-29 | - |
dc.date.issued | 2023-05 | - |
dc.identifier.issn | 1010-5182 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/89037 | - |
dc.description.abstract | This study aims to confirm the effectiveness and safety of a prabotulinumtoxin type A (praBTX-A) injection in patients with bruxism and masseter hypertrophy. The study included patients who ground or clenched their teeth while sleeping and had computed tomography (CT) scans that showed a maximum thickness of the masseter muscle of 15 mm or more. The praBTX-A was administered bilaterally into the masseter muscles; 15 U/side for group 1, 25 U/side for group 2, and 35 U/side for group 3. CT scans and bruxism questionnaires were conducted before and eight weeks after the injection. Thirty-seven patients were enrolled, but three dropped out due to loss of follow-up. After injection, masseter thickness decreased to 15.1 & PLUSMN; 2.0 mm for group 1, 14.3 & PLUSMN; 2.9 mm for group 2, and 13.4 & PLUSMN; 1.8 mm for group 3 (p = 0.043). Group 3 showed a statistically significant lower masseter thickness compared to group 1 (p = 0.039). Both subjective and objective frequencies of bruxism decreased for all groups, but there were no significant differences in either subjective (p = 0.396) or objective frequencies (p = 0.87) between the groups after the injection. The results of this study suggest that praBTX-A injection is a safe and effective treatment for bruxism and masseter hypertrophy. A dosage of 35 IU/side can effectively decrease masseter thickness and relieve bruxism symptoms. Even the minimum dosage of 15 IU/side can contribute to improvements in bruxism symptoms. This investigation provides valuable information for managing bruxism that is associated with hypertrophic masseter muscles. & COPY; 2023 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | CHURCHILL LIVINGSTONE | - |
dc.relation.isPartOf | JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY | - |
dc.title | Clinical investigation of botulinum toxin (prabotulinumtoxin A) for bruxism related to masseter muscle hypertrophy: A prospective study | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 001049916200001 | - |
dc.identifier.doi | 10.1016/j.jcms.2023.05.005 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY, v.51, no.5, pp.332 - 337 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85164431159 | - |
dc.citation.endPage | 337 | - |
dc.citation.startPage | 332 | - |
dc.citation.title | JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY | - |
dc.citation.volume | 51 | - |
dc.citation.number | 5 | - |
dc.contributor.affiliatedAuthor | Cheon, Young Woo | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Botulinum toxins | - |
dc.subject.keywordAuthor | Bruxism | - |
dc.subject.keywordAuthor | Masseter muscle | - |
dc.subject.keywordPlus | DOUBLE-BLIND | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.subject.keywordPlus | MODERATE | - |
dc.subject.keywordPlus | SAFETY | - |
dc.subject.keywordPlus | PAIN | - |
dc.relation.journalResearchArea | Dentistry, Oral Surgery & Medicine | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalWebOfScienceCategory | Dentistry, Oral Surgery & Medicine | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.