Pancreatic Beta-cell Dysfunction in Type 2 Diabetes
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Khin, Phyu Phyu | - |
dc.contributor.author | Lee, Jong Han | - |
dc.contributor.author | Jun, Hee-Sook | - |
dc.date.accessioned | 2023-09-19T01:40:09Z | - |
dc.date.available | 2023-09-19T01:40:09Z | - |
dc.date.created | 2023-03-26 | - |
dc.date.issued | 2023-01 | - |
dc.identifier.issn | 1721-727X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/89112 | - |
dc.description.abstract | Pancreatic β-cells produce and secrete insulin to maintain blood glucose levels within a narrow range. Defects in the function and mass of β-cells play a significant role in the development and progression of diabetes. Increased β-cell deficiency and β-cell apoptosis are observed in the pancreatic islets of patients with type 2 diabetes. At an early stage, β-cells adapt to insulin resistance, and their insulin secretion increases, but they eventually become exhausted, and the β-cell mass decreases. Various causal factors, such as high glucose, free fatty acids, inflammatory cytokines, and islet amyloid polypeptides, contribute to the impairment of β-cell function. Therefore, the maintenance of β-cell function is a logical approach for the treatment and prevention of diabetes. In this review, we provide an overview of the role of these risk factors in pancreatic β-cell loss and the associated mechanisms. A better understanding of the molecular mechanisms underlying pancreatic β-cell loss will provide an opportunity to identify novel therapeutic targets for type 2 diabetes. © The Author(s) 2023. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SAGE Publications Inc. | - |
dc.relation.isPartOf | European Journal of Inflammation | - |
dc.title | Pancreatic Beta-cell Dysfunction in Type 2 Diabetes | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 001061140200001 | - |
dc.identifier.doi | 10.1177/1721727X231154152 | - |
dc.identifier.bibliographicCitation | European Journal of Inflammation, v.21 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85147226899 | - |
dc.citation.title | European Journal of Inflammation | - |
dc.citation.volume | 21 | - |
dc.contributor.affiliatedAuthor | Khin, Phyu Phyu | - |
dc.contributor.affiliatedAuthor | Jun, Hee-Sook | - |
dc.type.docType | Review | - |
dc.subject.keywordAuthor | glucotoxicity | - |
dc.subject.keywordAuthor | lipotoxicity | - |
dc.subject.keywordAuthor | mechanisms | - |
dc.subject.keywordAuthor | β-cell death | - |
dc.subject.keywordAuthor | β-cell loss | - |
dc.subject.keywordPlus | STIMULATED INSULIN-SECRETION | - |
dc.subject.keywordPlus | UNFOLDED PROTEIN RESPONSE | - |
dc.subject.keywordPlus | FATTY-ACID PALMITATE | - |
dc.subject.keywordPlus | ELECTRICAL-ACTIVITY | - |
dc.subject.keywordPlus | EUROPEAN SUBJECTS | - |
dc.subject.keywordPlus | ER STRESS | - |
dc.subject.keywordPlus | AUTOPHAGY | - |
dc.subject.keywordPlus | GLUCOSE | - |
dc.subject.keywordPlus | MASS | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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