Modified Korean MIND Diet: A Nutritional Intervention for Improved Cognitive Function in Elderly Women through Mitochondrial Respiration, Inflammation Suppression, and Amino Acid Metabolism Regulation
- Authors
- Kang, Eun Young; Kim, Do-Young; Kim, Hyun Kyung; Kim, Tae Hoon; Kim, Wooki; Lei, Cao; Lee, Sang-gil; Gang, Gyoungok; Shin, Minhye; Kim, Jun-Mo; Go, Gwang-woong
- Issue Date
- Oct-2023
- Publisher
- WILEY
- Keywords
- K-MIND diet; metabolome; mild cognitive impairment; multi-omics analysis; transcriptome
- Citation
- MOLECULAR NUTRITION & FOOD RESEARCH, v.67, no.20
- Journal Title
- MOLECULAR NUTRITION & FOOD RESEARCH
- Volume
- 67
- Number
- 20
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/89402
- DOI
- 10.1002/mnfr.202300329
- ISSN
- 1613-4125
- Abstract
- Scope: Mild cognitive impairment is associated with a high prevalence of dementia. The study examines the benefits of a modified Korean MIND (K-MIND) diet and explores biomarkers using multi-omics analysis.Methods and results: The K-MIND diet, tailored to the elderly Korean population, includes perilla oil, milk, or fermented milk, and avoids alcohol consumption. As a result, the K-MIND diet significantly improves subjects "orientation to place" in the Korean version of the Mini-Mental State Examination, 2nd edition test. According to multi-omics analysis, the K-MIND diet upregulates genes associated with mitochondrial respiration, including ubiquinone oxidoreductase, cytochrome C oxidase, and ATP synthase, and immune system processes, and downregulates genes related to nuclear factor kappa B activity and inflammatory responses. In addition, K-MIND affects the metabolic pathways of glycine, serine, threonine, tryptophan, and sphingolipids, which are closely linked to cognitive function through synthesis of neurotransmitters and structures of brain cell membranes.Conclusion: The findings imply that the K-MIND diet improves cognitive function by upregulating key genes involved in oxidative phosphorylation and downregulating pro-inflammatory cytokines.
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