Efficacy and Safety of Prolonged-Release Melatonin for Primary Insomnia in Elderly Patients
DC Field | Value | Language |
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dc.contributor.author | Park, Young-Min | - |
dc.contributor.author | Lee, So-Jin | - |
dc.contributor.author | Lee, Jin-Seong | - |
dc.contributor.author | Na, Kyoung-Sae | - |
dc.contributor.author | Kang, Seung-Gul | - |
dc.contributor.author | Lee, Bun-Hee | - |
dc.contributor.author | Yoon, Ho-Kyoung | - |
dc.contributor.author | Kim, Eui-Joong | - |
dc.date.accessioned | 2023-10-26T01:40:19Z | - |
dc.date.available | 2023-10-26T01:40:19Z | - |
dc.date.created | 2023-10-26 | - |
dc.date.issued | 2023-09 | - |
dc.identifier.issn | 2635-9162 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/89458 | - |
dc.description.abstract | Objective: Insomnia, a prevalent sleep disorder affecting the elderly, necessitates effective and safe treatment options. This study explores the potential of the prolonged-release melatonin (Circadin®) addressing insomnia in elderly patients. Methods: The 8-week prospective observational study involved 115 participants, assessing sleep parameters using the Pittsburgh Sleep Quality Index (PSQI) and WHO-5 Well-being Index. The prolonged-release melatonin (2 mg) was administered nightly, and assessments were conducted at baseline, 4 weeks, and 8 weeks. Results: Both per protocol and last observation carried forward (LOCF) analyses consistently revealed significant improvements in sleep latency, total sleep time, sleep efficiency, and overall well-being. Notably, sleep latency decreased after 4 and 8 weeks, while total sleep time and sleep efficiency increased, reflecting longer and more restful sleep. The WHO-5 Well-being Index exhibited noticeable enhancement. Adverse events, including dizziness and heartburn, were manageable. Despite a high dropout rate, this drug’s potential as an efficacious and safe treatment option for elderly insomnia patients was evident, aligned with prior research. Conclusion: The prolonged-release formulation’s resemblance to the natural circadian rhythm of melatonin release offers advantages over conventional medications. This study contributes to understanding the prolonged-release melatonin’s promise as a valuable therapeutic alternative, encouraging further investigation into its long-term effects and optimal implementation. Copyright © 2023 Korean Academy of Sleep Medicine. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Korean Society of Sleep Medicine | - |
dc.relation.isPartOf | Chronobiology in Medicine | - |
dc.title | Efficacy and Safety of Prolonged-Release Melatonin for Primary Insomnia in Elderly Patients | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.doi | 10.33069/cim.2023.0021 | - |
dc.identifier.bibliographicCitation | Chronobiology in Medicine, v.5, no.3, pp.138 - 143 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85174386137 | - |
dc.citation.endPage | 143 | - |
dc.citation.startPage | 138 | - |
dc.citation.title | Chronobiology in Medicine | - |
dc.citation.volume | 5 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | Na, Kyoung-Sae | - |
dc.contributor.affiliatedAuthor | Kang, Seung-Gul | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Circadin | - |
dc.subject.keywordAuthor | Elderly | - |
dc.subject.keywordAuthor | Insomnia | - |
dc.subject.keywordAuthor | Melatonin | - |
dc.description.journalRegisteredClass | scopus | - |
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