Effects of the APOE ε4 Allele on the Relationship Between Tau and Amyloid-β in Early- and Late-Onset Alzheimer's Disease
DC Field | Value | Language |
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dc.contributor.author | Kang, Jae Myeong | - |
dc.contributor.author | Shin, Jeong-Hyeon | - |
dc.contributor.author | Kim, Woo-Ram | - |
dc.contributor.author | Seo, Seongho | - |
dc.contributor.author | Seo, Haeun | - |
dc.contributor.author | Lee, Sang-Yoon | - |
dc.contributor.author | Park, Kee Hyung | - |
dc.contributor.author | Na, Duk L. | - |
dc.contributor.author | Okamura, Nobuyuki | - |
dc.contributor.author | Seong, Joon-Kyoung | - |
dc.contributor.author | Noh, Young | - |
dc.date.accessioned | 2023-10-28T02:40:34Z | - |
dc.date.available | 2023-10-28T02:40:34Z | - |
dc.date.created | 2023-10-28 | - |
dc.date.issued | 2023-08 | - |
dc.identifier.issn | 1387-2877 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/89473 | - |
dc.description.abstract | Background: Little is known regarding the differential effects of the apolipoprotein E (APOE) epsilon 4 on the regional topography of amyloid and tau in patients with both early-onset (EOAD) and late-onset Alzheimer's disease (LOAD). Objective: To compare the distribution and association of tau, amyloid, and cortical thickness among groups classified by the presence of APOE epsilon 4 allele and onset age. Methods: A total of 165 participants including 54 EOAD patients (29 epsilon 4-; 25 epsilon 4+), 45 LOAD patients (21 epsilon 4-; 24 epsilon 4+), and 66 age-matched controls underwent 3T MRI, F-18-THK5351 (THK) and F-18-flutemetamol (FLUTE) PET scans, APOE genotyping, and neuropsychological tests. Data for voxel-wise and standardized uptake values from PET scans were analyzed in the context of APOE and age at onset. Results: EOAD epsilon 4- patients showed greater THK retention in the association cortices, whereas their EOAD epsilon 4+ counterparts had more retention in medial temporal areas. THK topography of LOAD epsilon 4+ was similar to EOAD epsilon 4 +. THK correlated positively with FLUTE and conversely with mean cortical thickness, being lowest in EOAD epsilon 4-, highest in LOAD epsilon 4-, and modest in epsilon 4+ groups. Even in the APOE epsilon 4+ groups, THK tended to correlate with FLUTE and mean cortical thickness in the inferior parietal region in EOAD and in the medial temporal region in LOAD. LOAD epsilon 4- manifested with prevalent small vessel disease markers and the lowest correlation between THK retention and cognition. Conclusion: Our observations suggest the differential effects of the APOE epsilon 4 on the relationship between tau and amyloid in EOAD and LOAD. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | IOS PRESS | - |
dc.relation.isPartOf | JOURNAL OF ALZHEIMERS DISEASE | - |
dc.title | Effects of the APOE ε4 Allele on the Relationship Between Tau and Amyloid-β in Early- and Late-Onset Alzheimer's Disease | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 001055512500030 | - |
dc.identifier.doi | 10.3233/JAD-230339 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ALZHEIMERS DISEASE, v.94, no.3, pp.1233 - 1246 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85166736697 | - |
dc.citation.endPage | 1246 | - |
dc.citation.startPage | 1233 | - |
dc.citation.title | JOURNAL OF ALZHEIMERS DISEASE | - |
dc.citation.volume | 94 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | Kang, Jae Myeong | - |
dc.contributor.affiliatedAuthor | Kim, Woo-Ram | - |
dc.contributor.affiliatedAuthor | Seo, Seongho | - |
dc.contributor.affiliatedAuthor | Seo, Haeun | - |
dc.contributor.affiliatedAuthor | Lee, Sang-Yoon | - |
dc.contributor.affiliatedAuthor | Park, Kee Hyung | - |
dc.contributor.affiliatedAuthor | Noh, Young | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Alzheimer&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordAuthor | amyloid | - |
dc.subject.keywordAuthor | APOE | - |
dc.subject.keywordAuthor | early-onset Alzheimer&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordAuthor | tau | - |
dc.subject.keywordPlus | APOLIPOPROTEIN-E | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | PATHOLOGY | - |
dc.subject.keywordPlus | AGE | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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