Polyphenolic Carbon Quantum Dots with Intrinsic Reactive Oxygen Species Amplification for Two-Photon Bioimaging and In Vivo Tumor Therapy
DC Field | Value | Language |
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dc.contributor.author | Dutta, Sayan Deb | - |
dc.contributor.author | Moniruzzaman, Md | - |
dc.contributor.author | Hexiu, Jin | - |
dc.contributor.author | Sarkar, Sourav | - |
dc.contributor.author | Ganguly, Keya | - |
dc.contributor.author | Patel, Dinesh K. | - |
dc.contributor.author | Mondal, Jagannath | - |
dc.contributor.author | Lee, Yong-Kyu | - |
dc.contributor.author | Acharya, Rumi | - |
dc.contributor.author | Kim, Jongsung | - |
dc.contributor.author | Lim, Ki-Taek | - |
dc.date.accessioned | 2023-12-15T15:08:29Z | - |
dc.date.available | 2023-12-15T15:08:29Z | - |
dc.date.issued | 2023-10 | - |
dc.identifier.issn | 1944-8244 | - |
dc.identifier.issn | 1944-8252 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/89518 | - |
dc.description.abstract | Recent studies indicate that mitochondrial dysfunctions and DNA damage have a critical influence on cell survival, which is considered one of the therapeutic targets for cancer therapy. In this study, we demonstrated a comparative study of the effect of polyphenolic carbon quantum dots (CQDs) on in vitro and in vivo antitumor efficacy. Dual emissive (green and yellow) shape specific polyphenolic CQDs (G-CQDs and Y-CQDs) were synthesized from easily available nontoxic precursors (phloroglucinol), and the antitumor property of the as-synthesized probe was investigated as compared to round-shaped blue emissive CQDs (B-CQDs) derived from well-reported precursor citric acid and urea. The B-CQDs had a nuclei-targeting property, and G-CQDs and Y-CQDs had mitochondria-targeting properties. We have found that the polyphenol containing CQDs (at a dose of 100 mu g mL(-1)) specifically attack mitochondria by excess accumulation, altering the metabolism, inhibiting branching pattern, imbalanced Bax/Bcl-2 homeostasis, and ultimately generating oxidative stress levels, leading to oxidative stress-induced cell death in cancer cells in vitro. We show that G-CQDs are the main cause of oxidative stress in cancer cells because of their ability to produce sufficient (OH-)-O-center dot and O-1(2) radicals, evidenced by electron paramagnetic resonance spectroscopy and a terephthalic acid test. Moreover, the near-infrared absorption properties of the CQDs were exhibited in two-photon (TP) emission, which was utilized for TP cellular imaging of cancer cells without photobleaching. The in vivo antitumor test further discloses that intratumoral injection of G-CQDs can significantly augment the treatment efficacy of subcutaneous tumors without any adverse effects on BalB/c nude mice. We believe that shape-specific polyphenolic CQD-based nanotheranostic agents have a potential role in tumor therapy, thus proving an insight on treatment of malignant cancers. | - |
dc.format.extent | 17 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | Polyphenolic Carbon Quantum Dots with Intrinsic Reactive Oxygen Species Amplification for Two-Photon Bioimaging and In Vivo Tumor Therapy | - |
dc.type | Article | - |
dc.identifier.wosid | 001096856100001 | - |
dc.identifier.doi | 10.1021/acsami.3c07547 | - |
dc.identifier.bibliographicCitation | ACS APPLIED MATERIALS & INTERFACES, v.15, no.45, pp 52083 - 52099 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85178367498 | - |
dc.citation.endPage | 52099 | - |
dc.citation.startPage | 52083 | - |
dc.citation.title | ACS APPLIED MATERIALS & INTERFACES | - |
dc.citation.volume | 15 | - |
dc.citation.number | 45 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | polyphenolic CQDs | - |
dc.subject.keywordAuthor | mitochondrial dysfunctions | - |
dc.subject.keywordAuthor | two-photon imaging | - |
dc.subject.keywordAuthor | oxidative stress | - |
dc.subject.keywordAuthor | nanotheranostics | - |
dc.subject.keywordPlus | SELECTIVE DETECTION | - |
dc.subject.keywordPlus | CANCER-CELLS | - |
dc.subject.keywordPlus | MITOCHONDRIA | - |
dc.subject.keywordPlus | TOXICITY | - |
dc.subject.keywordPlus | ACID | - |
dc.subject.keywordPlus | CYTOTOXICITY | - |
dc.subject.keywordPlus | FLUORESCENT | - |
dc.subject.keywordPlus | DAMAGE | - |
dc.subject.keywordPlus | VITRO | - |
dc.subject.keywordPlus | CDTE | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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