Effect of BCR::ABL1 transcript type and droplet digital polymerase chain reaction on successful treatment-free remission in chronic myeloid leukemia patients who discontinued tyrosine kinase inhibitoropen access
- Authors
- Park, Hyunkyung; Kim, Hyeong-Joon; Sohn, Sang-Kyun; Baik, Yoonsuk; Kim, Dongho; Lee, Sung-Yeoun; Kong, Jee Hyun; Kim, Hawk; Shin, Dong-Yeop; Ahn, Jae-Sook; Park, Jinny; Park, Seonyang; Kim, Inho
- Issue Date
- Nov-2023
- Publisher
- SAGE PUBLICATIONS LTD
- Keywords
- chronic myeloid leukemia; droplet digital polymerase chain reaction; transcript type; treatment-free remission; tyrosine kinase inhibitor
- Citation
- THERAPEUTIC ADVANCES IN HEMATOLOGY, v.14
- Journal Title
- THERAPEUTIC ADVANCES IN HEMATOLOGY
- Volume
- 14
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/89564
- DOI
- 10.1177/20406207231205637
- ISSN
- 2040-6207
2040-6215
- Abstract
- Background: Droplet digital polymerase chain reaction (ddPCR) is an exact method of measurement.Objectives: We conducted this study to identify the prognostic factors for successful treatment-free remission in patients with chronic-phase chronic myeloid leukemia who discontinued tyrosine kinase inhibitors (TKIs). We also aimed to validate ddPCR for predicting molecular relapse.Design: This is a prospective, multicenter study.Methods: We enrolled patients treated with TKIs for at least 3 years with a confirmed sustained deep molecular response (DMR) for at least 1 year. TKI was re-administered in patients who experienced the loss of major molecular response (MMR).Results: A total of 66 patients from five institutions in South Korea were enrolled. During a median follow-up period of 16.5 months, 29/66 (43.9%) patients experienced molecular relapse; the probability of molecular relapse-free survival (RFS) at 6 or 12 months after TKI discontinuation was 65.6% or 57.8%, respectively, with most molecular relapses occurring within the first 7 months. All patients who lost MMR were re-treated with TKI, and all re-achieved MMR at a median of 2.8 months. E14a2 transcript type (p = 0.005) and longer DMR duration (>= 48 months) prior to TKI discontinuation (p = 0.002) were associated with prolonged molecular RFS and with sustained DMR. Patients with both e13a2 transcript type and detectable BCR::ABL1 (>= MR5.0) by ddPCR at the time of TKI discontinuation showed shorter duration of molecular RFS (p = 0.015).Conclusion: Our data suggest that transcript type and BCR::ABL1 transcript levels on ddPCR should be taken into consideration when deciding whether to discontinue TKI therapy.
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