The Effects of Flavonol and Flavone Glucuronides from Potentilla chinensis Leaves on TNF-α-Exposed Normal Human Dermal Fibroblasts
DC Field | Value | Language |
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dc.contributor.author | Choi, Yea Jung | - |
dc.contributor.author | Lee, So Young | - |
dc.contributor.author | Son, So-Ri | - |
dc.contributor.author | Park, Jun Yeon | - |
dc.contributor.author | Jang, Dae Sik | - |
dc.contributor.author | Lee, Sullim | - |
dc.date.accessioned | 2023-12-15T15:10:11Z | - |
dc.date.available | 2023-12-15T15:10:11Z | - |
dc.date.issued | 2023-10 | - |
dc.identifier.issn | 2076-3921 | - |
dc.identifier.issn | 2076-3921 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/89591 | - |
dc.description.abstract | Skin aging is a complex biological process influenced by a variety of factors, including UV radiation. UV radiation accelerates collagen degradation via the production of reactive oxygen species (ROS) and cytokines, including TNF-alpha. In a prior investigation, the inhibitory properties of flavonol and flavone glucuronides derived from Potentilla chinensis on TNF-alpha-induced ROS and MMP-1 production were explored. Consequently, we verified the skin-protective effects of these flavonol and flavone glucuronides, including potentilloside A, from P. chinensis, and conducted a structure-activity relationship analysis as part of our ongoing research. We investigated the protective effects of the extract and its 11 isolates on TNF-alpha-stimulated normal human dermal fibroblasts (NHDFs). Ten flavonol and flavone glucuronides significantly inhibited ROS generation (except for 7) and suppressed MMP-1 secretion, except for 2. In contrast, six isolates (1, 5, 6, 11, 9, 10, and 11) showed a significant reverse effect on COLIA1 secretion. Comparing the three experimental results of each isolate, potentilloside A (1) showed the most potent skin cell-protective effect among the isolates. Evaluation of the signaling pathway of potentilloside A in TNF-alpha-stimulated NHDF revealed that potentilloside A inhibits the phosphorylation of ERK, JNK, and c-Jun. Taken together, these results suggest that compounds isolated from P. chinensis, especially potentilloside A, can be used to inhibit skin damage, including aging. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | MDPI | - |
dc.title | The Effects of Flavonol and Flavone Glucuronides from Potentilla chinensis Leaves on TNF-α-Exposed Normal Human Dermal Fibroblasts | - |
dc.type | Article | - |
dc.identifier.wosid | 001099622800001 | - |
dc.identifier.doi | 10.3390/antiox12101803 | - |
dc.identifier.bibliographicCitation | ANTIOXIDANTS, v.12, no.10 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85174890445 | - |
dc.citation.title | ANTIOXIDANTS | - |
dc.citation.volume | 12 | - |
dc.citation.number | 10 | - |
dc.type.docType | Article | - |
dc.publisher.location | 스위스 | - |
dc.subject.keywordAuthor | flavonol glucuronide | - |
dc.subject.keywordAuthor | flavone glucuronide | - |
dc.subject.keywordAuthor | potentilloside A | - |
dc.subject.keywordAuthor | ROS | - |
dc.subject.keywordAuthor | MMP-1 | - |
dc.subject.keywordAuthor | COLIA1 | - |
dc.subject.keywordPlus | ULTRAVIOLET-RADIATION | - |
dc.subject.keywordPlus | TGF-BETA/SMAD | - |
dc.subject.keywordPlus | SKIN | - |
dc.subject.keywordPlus | MMP-1 | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | UVB | - |
dc.subject.keywordPlus | PATHWAYS | - |
dc.subject.keywordPlus | LIGHT | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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