Xinghamide A, a New Cyclic Nonapeptide Found in Streptomyces xinghaiensis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Um, Soohyun | - |
dc.contributor.author | Lee, Jaeyoun | - |
dc.contributor.author | Kim, Sung Jin | - |
dc.contributor.author | Cho, Kyung A. | - |
dc.contributor.author | Kang, Ki Sung | - |
dc.contributor.author | Kim, Seung Hyun | - |
dc.date.accessioned | 2023-12-15T15:10:41Z | - |
dc.date.available | 2023-12-15T15:10:41Z | - |
dc.date.issued | 2023-10 | - |
dc.identifier.issn | 1660-3397 | - |
dc.identifier.issn | 1660-3397 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/89620 | - |
dc.description.abstract | Xinghamide A (1), a new nonapeptide, was discovered in Streptomyces xinghaiensis isolated from a halophyte, Suaeda maritima (L.) Dumort. Based on high-resolution mass and NMR spectroscopic data, the planar structure of 1 was established, and, in particular, the sequence of nine amino acids was determined with ROESY and HMBC NMR spectra. The absolute configurations of the alpha-carbon of each amino acid residue were determined with 1-fluoro-2,4-dinitrophenyl-l-and -d-leucine amide (Marfey's reagents) and 2,3,4,6-tetra-O-acetyl-beta-d-glucopyranosyl isothiocyanate, followed by LC-MS analysis. The anti-inflammatory activity of xinghamide A (1) was evaluated by inhibitory abilities against the nitric oxide (NO) secretion and cyclooxygenase-2 (COX-2) expression in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | MDPI | - |
dc.title | Xinghamide A, a New Cyclic Nonapeptide Found in Streptomyces xinghaiensis | - |
dc.type | Article | - |
dc.identifier.wosid | 001094350200001 | - |
dc.identifier.doi | 10.3390/md21100509 | - |
dc.identifier.bibliographicCitation | MARINE DRUGS, v.21, no.10 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85175028666 | - |
dc.citation.title | MARINE DRUGS | - |
dc.citation.volume | 21 | - |
dc.citation.number | 10 | - |
dc.type.docType | Article | - |
dc.publisher.location | 스위스 | - |
dc.subject.keywordAuthor | nonapeptide | - |
dc.subject.keywordAuthor | halophile | - |
dc.subject.keywordAuthor | Streptomyces xinghaiensis | - |
dc.subject.keywordAuthor | anti-inflammation | - |
dc.subject.keywordPlus | SOCIAL-BEHAVIOR | - |
dc.subject.keywordPlus | NITRIC-OXIDE | - |
dc.subject.keywordPlus | VASOPRESSIN | - |
dc.subject.keywordPlus | PEPTIDES | - |
dc.subject.keywordPlus | OXYTOCIN | - |
dc.subject.keywordPlus | COX-2 | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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