Organoid-Based Human Stomach Micro-Physiological System to Recapitulate the Dynamic Mucosal Defense Mechanism
DC Field | Value | Language |
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dc.contributor.author | Jeong, Hye-Jin | - |
dc.contributor.author | Park, Ji-Hyeon | - |
dc.contributor.author | Kang, Joo H. H. | - |
dc.contributor.author | Sabate del Rio, Jonathan | - |
dc.contributor.author | Kong, Seong-Ho | - |
dc.contributor.author | Park, Tae-Eun | - |
dc.date.accessioned | 2023-12-18T02:30:18Z | - |
dc.date.available | 2023-12-18T02:30:18Z | - |
dc.date.issued | 2023-09 | - |
dc.identifier.issn | 2198-3844 | - |
dc.identifier.issn | 2198-3844 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/89663 | - |
dc.description.abstract | Several stomach diseases are attributed to the dysregulation of physiological function of gastric mucosal barrier by pathogens. Gastric organoids are a promising tool to develop treatment strategies for gastric infections. However, their functional features of in vivo gastric mucosal barrier and host-microbe interactions are limited due to the lack of physiological stimuli. Herein, a human stomach micro-physiological system (hsMPS) with physiologically relevant gastric mucosal defense system is described based on the combination of organoid and MPS technology. A fluid flow enhanced epithelial-mesenchymal interaction in the hsMPS enables functional maturation of gastric epithelial cells, which allows for the recreation of mesh-like mucus layer containing high level of mucus protective peptides and well-developed epithelial junctional complexes. Furthermore, gastroprotection mechanisms against Helicobacter pylori (H. pylori) are successfully demonstrated in this system. Therefore, hsMPS represents a new in vitro tool for research where gastric mucosal defense mechanism is pivotal for developing therapeutic strategies. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | WILEY | - |
dc.title | Organoid-Based Human Stomach Micro-Physiological System to Recapitulate the Dynamic Mucosal Defense Mechanism | - |
dc.type | Article | - |
dc.identifier.wosid | 001040084900001 | - |
dc.identifier.doi | 10.1002/advs.202300164 | - |
dc.identifier.bibliographicCitation | ADVANCED SCIENCE, v.10, no.27 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85166264768 | - |
dc.citation.title | ADVANCED SCIENCE | - |
dc.citation.volume | 10 | - |
dc.citation.number | 27 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | gastric mucosal defense mechanism | - |
dc.subject.keywordAuthor | Helicobacter pylori | - |
dc.subject.keywordAuthor | human gastric organoids | - |
dc.subject.keywordAuthor | micro-physiological system | - |
dc.subject.keywordAuthor | telocytes | - |
dc.subject.keywordAuthor | Trefoil factor 1 | - |
dc.subject.keywordPlus | HELICOBACTER-PYLORI INFECTION | - |
dc.subject.keywordPlus | CELL | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | STEM | - |
dc.subject.keywordPlus | SINGLE | - |
dc.subject.keywordPlus | POPULATIONS | - |
dc.subject.keywordPlus | EXPANSION | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.subject.keywordPlus | BARRIER | - |
dc.subject.keywordPlus | MUC5AC | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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