Efficacy of Prolonged-Release Melatonin Administration in Elderly Patients With Treatment Resistant Insomnia: A Post-Hoc Analysis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Young-Min | - |
dc.contributor.author | Lee, So-Jin | - |
dc.contributor.author | Lee, Jin-Seong | - |
dc.contributor.author | Na, Kyoung-Sae | - |
dc.contributor.author | Kang, Seung-Gul | - |
dc.contributor.author | Lee, Bun-Hee | - |
dc.contributor.author | Yoon, Ho-Kyoung | - |
dc.contributor.author | Kim, Eui-Joong | - |
dc.date.accessioned | 2024-01-08T15:00:22Z | - |
dc.date.available | 2024-01-08T15:00:22Z | - |
dc.date.issued | 2023-12 | - |
dc.identifier.issn | 2635-9162 | - |
dc.identifier.issn | 2635-9162 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/89986 | - |
dc.description.abstract | Objective: Melatonin, both immediate and prolonged-release formulations, has been explored as an adjunctive treatment for insomnia, with prolonged-release melatonin demonstrating enhanced efficacy compared to its immediate-release counterpart. However, there remains a gap in understanding its effectiveness specifically in individuals with treatment-resistant insomnia, who continue to experience sleep difficulties despite using traditional hypnotic medications. Methods: An 8-week prospective, open-label, observational study was conducted on 115 patients aged 55 years or older with insomnia several years ago. This is a post-hoc analysis, which was performed on 63 out of 115 patients who were already taking hypnotics and still reported symptoms of insomnia. Per protocol (n=40) and last observation carried forward (LOCF) approaches (n=63) were used, assessing changes in sleep indicators after administering 2 mg of prolonged-release melatonin. Psychometric scales including Pittsburgh Sleep Quality Index (PSQI) and WHO-5 Well-Being Index were used for evaluation at baseline, week 4, and week 8. Results: The per protocol and LOCF analysis revealed substantial improvements in sleep latency, total sleep time, sleep efficiency, and total PSQI scores after 8 weeks of prolonged-release melatonin treatment. The LOCF analysis also revealed WHO-5 Well-Being Index significantly increased. Compared to prolonged-release melatonin monotherapy group with combination therapy group (adding prolonged-release melatonin to previous hypnotics) at baseline, 4 weeks, and 8 weeks after treatment, most variables did not differ between two groups in the per protocol and LOCF analysis. However, only WHO-5 Well-Being Index was higher in monotherapy group than in combination group at 4 weeks and 8 weeks after prolonged-release melatonin treatment in the per protocol analysis. Conclusion: Prolonged-release melatonin demonstrated notable efficacy in ameliorating sleep latency, duration, efficiency, and overall quality in treatment-resistant insomnia patients. The study highlights its potential as a treatment avenue for this challenging cohort, prompting further exploration into its benefits, particularly in improving overall well-being, and advocating for expanded research in this domain. © 2023 Korean Academy of Sleep Medicine. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Korean Society of Sleep Medicine | - |
dc.title | Efficacy of Prolonged-Release Melatonin Administration in Elderly Patients With Treatment Resistant Insomnia: A Post-Hoc Analysis | - |
dc.type | Article | - |
dc.identifier.doi | 10.33069/cim.2023.0030 | - |
dc.identifier.bibliographicCitation | Chronobiology in Medicine, v.5, no.4, pp 172 - 177 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85181094967 | - |
dc.citation.endPage | 177 | - |
dc.citation.startPage | 172 | - |
dc.citation.title | Chronobiology in Medicine | - |
dc.citation.volume | 5 | - |
dc.citation.number | 4 | - |
dc.type.docType | Article | - |
dc.publisher.location | South Korea | - |
dc.subject.keywordAuthor | Insomnia | - |
dc.subject.keywordAuthor | Melatonin | - |
dc.subject.keywordAuthor | Prolonged release | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.