The Impact of Melatonin on Inflammatory Status and Quality of Life
DC Field | Value | Language |
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dc.contributor.author | Chae, Boram | - |
dc.contributor.author | Park, Young-Min | - |
dc.contributor.author | Lee, So-Jin | - |
dc.contributor.author | Lee, Jin-Seong | - |
dc.contributor.author | Kang, Seung-Gul | - |
dc.contributor.author | Na, Kyoung-Sae | - |
dc.contributor.author | Kim, Eui-Joong | - |
dc.contributor.author | Yoon, Ho-Kyoung | - |
dc.date.accessioned | 2024-01-10T02:00:18Z | - |
dc.date.available | 2024-01-10T02:00:18Z | - |
dc.date.issued | 2023-12 | - |
dc.identifier.issn | 2635-9162 | - |
dc.identifier.issn | 2635-9162 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/90008 | - |
dc.description.abstract | Objective: This study aimed to assess whether the use of melatonin as an initial insomnia treatment can enhance inflammatory status and quality of life (QoL). We also explored a potential correlation between these improvements and sleep pattern ameliorations and whether baseline status correlated to differences in sleep quality, inflammatory status, and QoL. Methods: We enrolled 67 subjects from 6 different hospitals who met Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) insomnia criteria. The patients took 2 mg per day of prolonged-release melatonin (PRM) for 8 weeks. We administered the Pittsburgh Sleep Quality Index (PSQI) to assess sleep quality and the WHO-5 Well-Being Index to assess QoL at baseline, week 4, and week 8. We measured tumor necrosis factor-alpha (TNF-α) levels to determine inflammatory status at baseline and week 8. Results: The mean global PSQI score declined significantly from 13.97 to 10.39 (p<0.001) after 8 weeks of PRM treatment. The mean WHO-5 Well-Being Index score improved significantly from 7.30 to 11.0 (p<0.001) over the study period. The mean TNF-α nonsignificantly declined from 0.62 to 0.60 (p=0.28). The PSQI improvement over 8 weeks was correlated to the baseline PSQI score (r=0.40, p=0.001). The decrease in TNF-α over 8 weeks was correlated to the baseline TNF-α level (r=0.43, p<0.001). Conclusion: This study reported measurable improvement in sleep quality and QoL after 8 weeks of PRM. Although the decrease in TNF-α level over 8 weeks was not significant, it showed correlation to the baseline TNF-α level. PRM can prevent excessive inflammation and may be beneficial in chronic inflammation involving TNF-α. © 2023 Korean Academy of Sleep Medicine. | - |
dc.format.extent | 4 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Korean Society of Sleep Medicine | - |
dc.title | The Impact of Melatonin on Inflammatory Status and Quality of Life | - |
dc.type | Article | - |
dc.identifier.doi | 10.33069/cim.2023.0028 | - |
dc.identifier.bibliographicCitation | Chronobiology in Medicine, v.5, no.4, pp 190 - 193 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85181235649 | - |
dc.citation.endPage | 193 | - |
dc.citation.startPage | 190 | - |
dc.citation.title | Chronobiology in Medicine | - |
dc.citation.volume | 5 | - |
dc.citation.number | 4 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Inflammation | - |
dc.subject.keywordAuthor | Insomnia | - |
dc.subject.keywordAuthor | Melatonin | - |
dc.subject.keywordAuthor | Quality of life | - |
dc.subject.keywordAuthor | Tumor necrosis factor-alpha | - |
dc.description.journalRegisteredClass | scopus | - |
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