Performance of non-invasive tests and histology for the prediction of clinical outcomes in patients with non-alcoholic fatty liver disease: an individual participant data meta-analysis
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dc.contributor.author | Mozes, Ferenc E. | - |
dc.contributor.author | Lee, Jenny A. | - |
dc.contributor.author | Vali, Yasaman | - |
dc.contributor.author | Alzoubi, Osama | - |
dc.contributor.author | Staufer, Katharina | - |
dc.contributor.author | Trauner, Michael | - |
dc.contributor.author | Paternostro, Rafael | - |
dc.contributor.author | Stauber, Rudolf E. | - |
dc.contributor.author | Holleboom, Adriaan G. | - |
dc.contributor.author | van Dijk, Anne-Marieke | - |
dc.contributor.author | Mak, Anne Linde | - |
dc.contributor.author | Boursier, Jerome | - |
dc.contributor.author | Loup, Marc de Saint | - |
dc.contributor.author | Shima, Toshihide | - |
dc.contributor.author | Bugianesi, Elisabetta | - |
dc.contributor.author | Gaia, Silvia | - |
dc.contributor.author | Armandi, Angelo | - |
dc.contributor.author | Shalimar | - |
dc.contributor.author | Lupsor-Platon, Monica | - |
dc.contributor.author | Wong, Vincent Wai-Sun | - |
dc.contributor.author | Li, Guanlin | - |
dc.contributor.author | Wong, Grace Lai-Hung | - |
dc.contributor.author | Cobbold, Jeremy | - |
dc.contributor.author | Karlas, Thomas | - |
dc.contributor.author | Wiegand, Johannes | - |
dc.contributor.author | Sebastiani, Giada | - |
dc.contributor.author | Tsochatzis, Emmanuel | - |
dc.contributor.author | Liguori, Antonio | - |
dc.contributor.author | Yoneda, Masato | - |
dc.contributor.author | Nakajima, Atsushi | - |
dc.contributor.author | Hagstrom, Hannes | - |
dc.contributor.author | Akbari, Camilla | - |
dc.contributor.author | Hirooka, Masashi | - |
dc.contributor.author | Chan, Wah-Kheong | - |
dc.contributor.author | Mahadeva, Sanjiv | - |
dc.contributor.author | Rajaram, Ruveena | - |
dc.contributor.author | Zheng, Ming-Hua | - |
dc.contributor.author | George, Jacob | - |
dc.contributor.author | Eslam, Mohammed | - |
dc.contributor.author | Petta, Salvatore | - |
dc.contributor.author | Pennisi, Grazia | - |
dc.contributor.author | Vigano, Mauro | - |
dc.contributor.author | Ridolfo, Sofia | - |
dc.contributor.author | Aithal, Guruprasad Padur | - |
dc.contributor.author | Palaniyappan, Naaventhan | - |
dc.contributor.author | Lee, Dae Ho | - |
dc.contributor.author | Ekstedt, Mattias | - |
dc.contributor.author | Nasr, Patrik | - |
dc.contributor.author | Cassinotto, Christophe | - |
dc.contributor.author | de Ledinghen, Victor | - |
dc.contributor.author | Berzigotti, Annalisa | - |
dc.contributor.author | Mendoza, Yuly P. | - |
dc.contributor.author | Noureddin, Mazen | - |
dc.contributor.author | Truong, Emily | - |
dc.contributor.author | Fournier-Poizat, Celine | - |
dc.contributor.author | Geier, Andreas | - |
dc.contributor.author | Martic, Miljen | - |
dc.contributor.author | Tuthill, Theresa | - |
dc.contributor.author | Anstee, Quentin M. | - |
dc.contributor.author | Harrison, Stephen A. | - |
dc.contributor.author | Bossuyt, Patrick M. | - |
dc.contributor.author | Pavlides, Michael | - |
dc.date.accessioned | 2024-01-16T12:30:55Z | - |
dc.date.available | 2024-01-16T12:30:55Z | - |
dc.date.issued | 2023-08 | - |
dc.identifier.issn | 2468-1253 | - |
dc.identifier.issn | 2468-1253 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/90120 | - |
dc.description.abstract | Background Histologically assessed liver fibrosis stage has prognostic significance in patients with non-alcoholic fatty liver disease (NAFLD) and is accepted as a surrogate endpoint in clinical trials for non-cirrhotic NAFLD. Our aim was to compare the prognostic performance of non-invasive tests with liver histology in patients with NAFLD. Methods This was an individual participant data meta-analysis of the prognostic performance of histologically assessed fibrosis stage (F0-4), liver stiffness measured by vibration-controlled transient elastography (LSM-VCTE), fibrosis-4 index (FIB-4), and NAFLD fibrosis score (NFS) in patients with NAFLD. The literature was searched for a previously published systematic review on the diagnostic accuracy of imaging and simple non-invasive tests and updated to Jan 12, 2022 for this study. Studies were identified through PubMed/MEDLINE, EMBASE, and CENTRAL, and authors were contacted for individual participant data, including outcome data, with a minimum of 12 months of follow-up. The primary outcome was a composite endpoint of all-cause mortality, hepatocellular carcinoma, liver transplantation, or cirrhosis complications (ie, ascites, variceal bleeding, hepatic encephalopathy, or progression to a MELD score >= 15). We calculated aggregated survival curves for trichotomised groups and compared them using stratified log-rank tests (histology: F0-2 vs F3 vs F4; LSM: <10 vs 10 to <20 vs >= 20 kPa; FIB-4: <1<middle dot>3 vs 1<middle dot>3 to <= 2<middle dot>67 vs >2<middle dot>67; NFS: <-1<middle dot>455 vs -1<middle dot>455 to <= 0<middle dot>676 vs >0<middle dot>676), calculated areas under the time-dependent receiver operating characteristic curves (tAUC), and performed Cox proportional-hazards regression to adjust for confounding. This study was registered with PROSPERO, CRD42022312226.Findings Of 65 eligible studies, we included data on 2518 patients with biopsy-proven NAFLD from 25 studies (1126 [44<middle dot>7%] were female, median age was 54 years [IQR 44-63), and 1161 [46<middle dot>1%] had type 2 diabetes). After a median follow-up of 57 months [IQR 33-91], the composite endpoint was observed in 145 (5<middle dot>8%) patients. Stratified log-rank tests showed significant differences between the trichotomised patient groups (p<0<middle dot>0001 for all comparisons). The tAUC at 5 years were 0<middle dot>72 (95% CI 0<middle dot>62-0<middle dot>81) for histology, 0<middle dot>76 (0<middle dot>70-0<middle dot>83) for LSM-VCTE, 0<middle dot>74 (0<middle dot>64-0<middle dot>82) for FIB-4, and 0<middle dot>70 (0<middle dot>63-0<middle dot>80) for NFS. All index tests were significant predictors of the primary outcome after adjustment for confounders in the Cox regression.Interpretation Simple non-invasive tests performed as well as histologically assessed fibrosis in predicting clinical outcomes in patients with NAFLD and could be considered as alternatives to liver biopsy in some cases. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER INC | - |
dc.title | Performance of non-invasive tests and histology for the prediction of clinical outcomes in patients with non-alcoholic fatty liver disease: an individual participant data meta-analysis | - |
dc.type | Article | - |
dc.identifier.wosid | 001084590000001 | - |
dc.identifier.doi | 10.1016/S2468-1253(23)00141-3 | - |
dc.identifier.bibliographicCitation | LANCET GASTROENTEROLOGY & HEPATOLOGY, v.8, no.8, pp 704 - 713 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85162866470 | - |
dc.citation.endPage | 713 | - |
dc.citation.startPage | 704 | - |
dc.citation.title | LANCET GASTROENTEROLOGY & HEPATOLOGY | - |
dc.citation.volume | 8 | - |
dc.citation.number | 8 | - |
dc.type.docType | Article | - |
dc.publisher.location | United States | - |
dc.subject.keywordPlus | FIBROSIS STAGE | - |
dc.subject.keywordPlus | NAFLD | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordPlus | BIOPSY | - |
dc.subject.keywordPlus | SYSTEM | - |
dc.subject.keywordPlus | SCORE | - |
dc.subject.keywordPlus | TIME | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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