Mammalian Models in Alzheimer’s Research: An Update
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sharma, Himadri | - |
dc.contributor.author | Chang, Keun-A | - |
dc.contributor.author | Hulme, John | - |
dc.contributor.author | An, Seong Soo A. | - |
dc.date.accessioned | 2024-01-16T12:30:57Z | - |
dc.date.available | 2024-01-16T12:30:57Z | - |
dc.date.issued | 2023-10 | - |
dc.identifier.issn | 2073-4409 | - |
dc.identifier.issn | 2073-4409 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/90127 | - |
dc.description.abstract | A form of dementia distinct from healthy cognitive aging, Alzheimer’s disease (AD) is a complex multi-stage disease that currently afflicts over 50 million people worldwide. Unfortunately, previous therapeutic strategies developed from murine models emulating different aspects of AD pathogenesis were limited. Consequently, researchers are now developing models that express several aspects of pathogenesis that better reflect the clinical situation in humans. As such, this review seeks to provide insight regarding current applications of mammalian models in AD research by addressing recent developments and characterizations of prominent transgenic models and their contributions to pathogenesis as well as discuss the advantages, limitations, and application of emerging models that better capture genetic heterogeneity and mixed pathologies observed in the clinical situation. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | MDPI | - |
dc.title | Mammalian Models in Alzheimer’s Research: An Update | - |
dc.type | Article | - |
dc.identifier.wosid | 001098266600001 | - |
dc.identifier.doi | 10.3390/cells12202459 | - |
dc.identifier.bibliographicCitation | Cells, v.12, no.20 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85175026303 | - |
dc.citation.title | Cells | - |
dc.citation.volume | 12 | - |
dc.citation.number | 20 | - |
dc.type.docType | Review | - |
dc.publisher.location | South Korea | - |
dc.subject.keywordAuthor | Alzheimer’s Disease | - |
dc.subject.keywordAuthor | mouse models | - |
dc.subject.keywordAuthor | non-human primate | - |
dc.subject.keywordAuthor | tau | - |
dc.subject.keywordAuthor | β-amyloid | - |
dc.subject.keywordPlus | AMYLOID PRECURSOR PROTEIN | - |
dc.subject.keywordPlus | NONHUMAN PRIMATE MODELS | - |
dc.subject.keywordPlus | TRANSGENIC MOUSE MODELS | - |
dc.subject.keywordPlus | A-BETA | - |
dc.subject.keywordPlus | APOLIPOPROTEIN-E | - |
dc.subject.keywordPlus | CEREBROSPINAL-FLUID | - |
dc.subject.keywordPlus | ANIMAL-MODELS | - |
dc.subject.keywordPlus | COGNITIVE IMPAIRMENT | - |
dc.subject.keywordPlus | SYNAPTIC DYSFUNCTION | - |
dc.subject.keywordPlus | CALORIE RESTRICTION | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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