Effect of intralymphatic allergen-specific immunotherapy on house dust mite in a murine model of allergic rhinitis
DC Field | Value | Language |
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dc.contributor.author | Jung, Joo Hyun | - |
dc.contributor.author | Kim, Kyeong Ah | - |
dc.contributor.author | Choi, Yun Sook | - |
dc.contributor.author | Kim, Seon Tae | - |
dc.date.accessioned | 2024-02-08T02:30:20Z | - |
dc.date.available | 2024-02-08T02:30:20Z | - |
dc.date.issued | 2023-10 | - |
dc.identifier.issn | 0001-6489 | - |
dc.identifier.issn | 1651-2251 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/90322 | - |
dc.description.abstract | Background: Intralymphatic immunotherapy (ILIT) is a promising alternative for the treatment of patients with allergic rhinitis, providing similar therapeutic efficacy to conventional allergen-specific immunotherapy (AIT). However, the allergic mechanism of ILIT is not completely known. Aim: The aim of this study was to determine the efficacy of ILIT in a house dust mite (HDM) mouse model of allergic rhinitis. Methods: BALB/c mice were divided into four groups: G1, control without allergy; G2, allergy sensitized with HDM; G3, allergy with ILIT (starting with HDM 1.25 mu g/mL); and G4, allergy with ILIT (starting with HDM 2.5 mu g/mL). After the murine model of allergic rhinitis with HDM was established, mice were administered an intralymphatic injection through the inguinal lymph nodes with HDM. Results: ILIT decreased serum total IgE level and eosinophil infiltration in the nasal mucosa. ILIT also decreased the expression levels of IL-13, IL-25, IL-33, IFN-gamma, IL-6, and IL-17, and increased the expression of FoxP3(+) T reg cells. Conclusions and significance: Our results suggest that ILIT regulates the specific immunotherapy immunologic mechanism by downregulating Th1, Th2, and Th17 cytokines and upregulating FoxP3(+) T reg cells in the HDM allergic mouse model. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.title | Effect of intralymphatic allergen-specific immunotherapy on house dust mite in a murine model of allergic rhinitis | - |
dc.type | Article | - |
dc.identifier.wosid | 001115914200001 | - |
dc.identifier.doi | 10.1080/00016489.2023.2273405 | - |
dc.identifier.bibliographicCitation | ACTA OTO-LARYNGOLOGICA, v.143, no.10, pp 867 - 875 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85179965671 | - |
dc.citation.endPage | 875 | - |
dc.citation.startPage | 867 | - |
dc.citation.title | ACTA OTO-LARYNGOLOGICA | - |
dc.citation.volume | 143 | - |
dc.citation.number | 10 | - |
dc.type.docType | Article; Early Access | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | Allergens | - |
dc.subject.keywordAuthor | Allergic rhinitis | - |
dc.subject.keywordAuthor | Allergy immunotherapy | - |
dc.subject.keywordAuthor | Immunotherapy | - |
dc.subject.keywordAuthor | Rhinitis | - |
dc.subject.keywordPlus | YOUNG-ADULTS | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | ASTHMA | - |
dc.relation.journalResearchArea | Otorhinolaryngology | - |
dc.relation.journalWebOfScienceCategory | Otorhinolaryngology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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