Relationship Between Amyloid Positivity and Sleep Characteristics in the Elderly With Subjective Cognitive Decline
DC Field | Value | Language |
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dc.contributor.author | Jo, Kyung Joon | - |
dc.contributor.author | Ho, SeongHee | - |
dc.contributor.author | Hong, Yun Jeong | - |
dc.contributor.author | Jeong, Jee Hyang | - |
dc.contributor.author | Kim, SangYun | - |
dc.contributor.author | Wang, Min Jeong | - |
dc.contributor.author | Choi, Seong Hye | - |
dc.contributor.author | Han, SeungHyun | - |
dc.contributor.author | Yang, Dong Won | - |
dc.contributor.author | Park, Kee Hyung | - |
dc.date.accessioned | 2024-02-09T01:30:18Z | - |
dc.date.available | 2024-02-09T01:30:18Z | - |
dc.date.issued | 2024-01 | - |
dc.identifier.issn | 1738-1495 | - |
dc.identifier.issn | 2384-0757 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/90345 | - |
dc.description.abstract | Background and Purpose: Alzheimer’s disease (AD) is a neurodegenerative disease characterized by a progressive decline in cognition and performance of daily activities. Recent studies have attempted to establish the relationship between AD and sleep. It is believed that patients with AD pathology show altered sleep characteristics years before clinical symptoms appear. This study evaluated the differences in sleep characteristics between cognitively asymptomatic patients with and without some amyloid burden. Methods: Sleep characteristics of 76 subjects aged 60 years or older who were diagnosed with subjective cognitive decline (SCD) but not mild cognitive impairment (MCI) or AD were measured using Fitbit® Alta HR, a wristwatch-shaped wearable device. Amyloid deposition was evaluated using brain amyloid plaque load (BAPL) and global standardized uptake value ratio (SUVR) from fluorine-18 florbetaben positron emission tomography. Each component of measured sleep characteristics was analyzed for statistically significant differences between the amyloid-positive group and the amyloid-negative group. Results: Of the 76 subjects included in this study, 49 (64.5%) were female. The average age of the subjects was 70.72±6.09 years when the study started. 15 subjects were classified as amyloid-positive based on BAPL. The average global SUVR was 1.598±0.263 in the amyloid-positive group and 1.187±0.100 in the amyloid-negative group. Time spent in slow-wave sleep (SWS) was significantly lower in the amyloid-positive group (39.4±13.1 minutes) than in the amyloid-negative group (49.5±13.1 minutes) (p=0.009). Conclusions: This study showed that SWS is different between the elderly SCD population with and without amyloid positivity. How SWS affects AD pathology requires further research. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 대한치매학회 | - |
dc.title | Relationship Between Amyloid Positivity and Sleep Characteristics in the Elderly With Subjective Cognitive Decline | - |
dc.type | Article | - |
dc.identifier.doi | 10.12779/dnd.2024.23.1.22 | - |
dc.identifier.bibliographicCitation | Dementia and Neurocognitive Disorders(대한치매학회지), v.23, no.1, pp 22 - 29 | - |
dc.identifier.kciid | ART003050148 | - |
dc.description.isOpenAccess | N | - |
dc.citation.endPage | 29 | - |
dc.citation.startPage | 22 | - |
dc.citation.title | Dementia and Neurocognitive Disorders(대한치매학회지) | - |
dc.citation.volume | 23 | - |
dc.citation.number | 1 | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Alzheimer Disease | - |
dc.subject.keywordAuthor | Cognitive Decline | - |
dc.subject.keywordAuthor | Sleep | - |
dc.subject.keywordAuthor | Slow-Wave | - |
dc.description.journalRegisteredClass | kci | - |
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