1,25-Dihydroxy Vitamin D3 Facilitates the M2 Polarization and β-Amyloid Uptake by Human Microglia in a TREM2-Dependent Manner
DC Field | Value | Language |
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dc.contributor.author | Thu, Vo Thuy Anh | - |
dc.contributor.author | Hoang, Thi Xoan | - |
dc.contributor.author | Kim, Jae Young | - |
dc.date.accessioned | 2024-02-09T02:00:17Z | - |
dc.date.available | 2024-02-09T02:00:17Z | - |
dc.date.issued | 2023-05 | - |
dc.identifier.issn | 2314-6133 | - |
dc.identifier.issn | 2314-6141 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/90350 | - |
dc.description.abstract | Alzheimer's disease (AD) is a neurodegenerative disorder characterized by dementia as the primary clinical symptom. The production and accumulation of aggregated beta-amyloid (A beta) in patient brain tissues is one of the hallmarks of AD pathogenesis. Microglia, brain-resident macrophages, produce inflammatory cytokines in response to A beta oligomers or fibrils exacerbating A beta pathology in AD. HMO6 cells were treated with A beta 42 in the presence or absence of 1,25-dihydroxy vitamin D-3 (1,25(OH)(2)D-3) to determine its potential immunomodulatory effects, and the expression of pro-/anti-inflammatory cytokines, M1/M2-associated markers, Toll-like receptors (TLRs), and triggering receptor expressed on myeloid cells 2 (TREM2) was examined. 1,25(OH)(2)D-3 was found to suppress A beta-induced expression of proinflammatory cytokines (TNF-alpha, IL-1 beta, and IL-6), M1 markers (CD86 and iNOS), and TLR2/4, whilst increasing the expression of anti-inflammatory cytokines (IL-4, IL-10, and CCL17) and M2 markers (CD206 and Arg-1). Furthermore, 1,25(OH)(2)D-3 promoted TREM2 expression and A beta uptake by HMO6 cells, and the enhancement of A beta uptake and M2 polarization was revealed to be TREM2-dependent. The findings of this study suggest that 1,25(OH)(2)D-3 facilitates M2 polarization and A beta uptake in a TREM2-dependent manner. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | HINDAWI LTD | - |
dc.title | 1,25-Dihydroxy Vitamin D3 Facilitates the M2 Polarization and β-Amyloid Uptake by Human Microglia in a TREM2-Dependent Manner | - |
dc.type | Article | - |
dc.identifier.wosid | 001002823400001 | - |
dc.identifier.doi | 10.1155/2023/3483411 | - |
dc.identifier.bibliographicCitation | BIOMED RESEARCH INTERNATIONAL, v.2023 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85160981631 | - |
dc.citation.title | BIOMED RESEARCH INTERNATIONAL | - |
dc.citation.volume | 2023 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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