Solanum melongena extract supplementation protected skeletal muscle and brain damage by regulation of BDNF/PGC1α/irisin pathway via brain function-related myokines in high-fat diet induced obese mice
DC Field | Value | Language |
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dc.contributor.author | Lee, Heaji | - |
dc.contributor.author | Kim, Sun Yeou | - |
dc.contributor.author | Lim, Yunsook | - |
dc.date.accessioned | 2024-02-09T16:30:18Z | - |
dc.date.available | 2024-02-09T16:30:18Z | - |
dc.date.issued | 2024-02 | - |
dc.identifier.issn | 0955-2863 | - |
dc.identifier.issn | 1873-4847 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/90357 | - |
dc.description.abstract | In this study, we investigated the protective effects of SM on skeletal muscle and brain damage by regulation of BDNF/PGC1 alpha/irisin pathway via brain function related myokines in high-fat diet-induced OB mice. OB was induced by high-fat diet for 6 weeks. SM extract (SME) was administered with 200 mg/kg BW (LSM) and 500 mg/kg BW (HSM) by oral gavage every day for 12 weeks. Behavior tests such as grip strength, Y-maze, and passive avoidance test were conducted to analyze muscle and cognitive function. Histopathological changes in skeletal muscle and brain were examined by hematoxylin and eosin staining and the protein levels of biomarkers related to oxidative stress, inflammation, protein degradation, neuro-plasticity, and cell cycling were measured by western blot. SME regulated morphological changes (muscle cross-sectional area: 1.23%, 1.40%; density of neurons in hippocampus:1.74%, 1.73%) in T2DM mice. Importantly, SME supplementation significantly increased several muscle-derived myokines which might influence the expression of neuronal markers in OB mice (FGF21: 1.27%, 1.34%; PGC1 alpha: 1.0%, 1.32%; IRISIN: 1.9%, 1.08%; BDNF: 1.35%, 1.23%). Accordingly, SME activated hippocampal neurotrophic factors including BDNF (1.0%, 1.2%) and its associated PGC1 alpha/irisin pathway (PGC1 alpha :1.1%, 1.1%; IRISIN:1.1%, 0.9%) significantly. This study demonstrated the possibliy that protective myokines increased by SME supplementation may contribute to neuro-protection in OB mice. Taken together, the current study suggests that SME can be used to prevent skeletal muscle and brain damage in OB by protecting against oxidative stress and inflammatin via modulation of the BDNF/PGC1 alpha/irisin pathway in the therapeutic approach of obese patients.(c) 2023 Elsevier Inc. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.title | Solanum melongena extract supplementation protected skeletal muscle and brain damage by regulation of BDNF/PGC1α/irisin pathway via brain function-related myokines in high-fat diet induced obese mice | - |
dc.type | Article | - |
dc.identifier.wosid | 001141343600001 | - |
dc.identifier.doi | 10.1016/j.jnutbio.2023.109537 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NUTRITIONAL BIOCHEMISTRY, v.124 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85182956164 | - |
dc.citation.title | JOURNAL OF NUTRITIONAL BIOCHEMISTRY | - |
dc.citation.volume | 124 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | Solanum melongena | - |
dc.subject.keywordAuthor | Obesity | - |
dc.subject.keywordAuthor | Sarcopenia | - |
dc.subject.keywordAuthor | Brain damage | - |
dc.subject.keywordAuthor | Myokines | - |
dc.subject.keywordAuthor | Neuro-protection | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | MITOCHONDRIAL DYSFUNCTION | - |
dc.subject.keywordPlus | CHLOROGENIC ACID | - |
dc.subject.keywordPlus | QUERCETIN | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | INJURY | - |
dc.subject.keywordPlus | PGC-1-ALPHA | - |
dc.subject.keywordPlus | SARCOPENIA | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | RATS | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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